Determination of salbutamol, amikacin and paromomycin sulfate by a novel sulfate polymeric membrane sensor based on 2,6-diphenyl 4-(4-methoxyphenyl) pyrylium perchlorate

A novel sulfate polymeric membrane sensor based on 2,6-diphenyl 4-(4-methoxyphenyl) pyrylium perchlorate (DMPP) as a sensing material is presented. The electrode displays a very low detection limit (4.0 x 10(-7) M) and wide working concentration range (8.0 x 10(-7)-1.0 x 10(-1) M). The sensor shows remarkable selectivity toward sulfate over most common organic and inorganic anions, including chloride, acetate, nitrate, nitrite, bromide, iodide, thiocyanate, phosphate, fluoride, sulfite, hydrogen sulfite, hydrogen carbonate, citrate, tartarate and oxalate. The sensor reveals a Nernstian behavior (slope of -29.7 +/- 0.5 mV per decade) in a wide pH range (3.0-9.5). The proposed sensor shows a short response time over the entire working range (similar to 15 s) and was successfully applied to the direct determination of salbutamol, amikacin and paromomycin sulfate.