Single-shot detection of bacterial endospores via coherent Raman spectroscopy

被引：121

作者：

Pestov, Dmitry ^{[1
,2
,3
]}

Wang, Xi ^{[1
,2
,3
]}

Ariunbold, Gombojav O. ^{[1
,2
,3
]}

Murawski, Robert K. ^{[1
,2
,3
]}

Sautenkov, Vladimir A. ^{[1
,2
,3
]}

Dogariu, Arthur ^{[4
]}

Sokolov, Alexei V. ^{[1
,2
,3
]}

Scully, Marian O. ^{[1
,2
,3
,4
]}

机构：

[1] Texas A&M Univ, Dept Phys, College Stn, TX 77843 USA

[2] Texas A&M Univ, Inst Quantum Studies, College Stn, TX 77843 USA

[3] Texas A&M Univ, Dept Chem Engn, College Stn, TX 77843 USA

[4] Princeton Univ, Dept Phys & Mat Sci Grp, Princeton, NJ 08544 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2008年 / 105卷 / 02期

关键词：

biohazard; CARS; hybrid; technique; identification;

D O I：

10.1073/pnas.0710427105

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Recent advances in coherent Raman spectroscopy hold exciting promise for many potential applications. For example, a technique, mitigating the nonresonant four-wave-mixing noise while maximizing the Raman-resonant signal, has been developed and applied to the problem of real-time detection of bacterial endospores. After a brief review of the technique essentials, we show how extensions of our earlier experimental work [Pestov D, et al. (2007) Science 316:265-268] yield single-shot identification of a small sample of Bacillus subtifis endospores (approximate to 10(4) spores). The results convey the utility of the technique and its potential for "on-the-fly" detection of biohazards, such as Bacillus anthracis. The application of optimized coherent anti-Stokes Raman scattering scheme to problems requiring chemical specificity and short signal acquisition times is demonstrated.

引用

页码：422 / 427

页数：6

共 40 条

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