A premenopausal woman with virilization secondary to an ovarian Leydig cell tumor

被引：9

作者：

Faria, Andre M. ^{[1
]}

Perez, Ricardo V. ^{[1
]}

Marcondes, Jose A. M. ^{[1
]}

Freire, Daniel S. ^{[1
]}

Blasbalg, Roberto ^{[2
]}

Soares, Jose, Jr. ^{[5
,6
]}

Simoes, Kleber ^{[4
]}

Hayashida, Sylvia A. Y. ^{[3
]}

Pereira, Maria A. A. ^{[1
]}

机构：

[1] Univ Sao Paulo, Sch Med, Dept Endocrinol, BR-05403000 Sao Paulo, Brazil

[2] Univ Sao Paulo, Sch Med, Dept Radiol, BR-05403000 Sao Paulo, Brazil

[3] Univ Sao Paulo, Sch Med, Dept Gynecol, BR-05403000 Sao Paulo, Brazil

[4] Univ Sao Paulo, Sch Med, Dept Pathol, BR-05403000 Sao Paulo, Brazil

[5] Univ Sao Paulo, Sch Med, Hosp Clin, BR-05403000 Sao Paulo, Brazil

[6] Univ Sao Paulo, Sch Med, Dept Nucl Med, Inst Heart, BR-05403000 Sao Paulo, Brazil

来源：

NATURE REVIEWS ENDOCRINOLOGY | 2011年 / 7卷 / 04期

关键词：

CLINICOPATHOLOGICAL ANALYSIS; TESTOSTERONE; LOCALIZATION; LAPAROSCOPY; PREVALENCE; MANAGEMENT; NEOPLASMS; HIRSUTISM; DIAGNOSIS; MASSES;

D O I：

10.1038/nrendo.2011.15

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background. A 33-year-old woman presented to an endocrinology clinic with a 5-year history of secondary amenorrhea. 2 years before presentation, she had noticed progressively worsening signs of virilization. Investigations. Measurement of levels of serum free and total testosterone, androstenedione, dehydroepiandrosterone sulfate and gonadotropins; transvaginal ultrasonography, abdominal and pelvic MRI and F-18-fluorodeoxyglucose PET imaging. Diagnosis. Virilization secondary to an ovarian Leydig cell tumor. Management. The patient underwent a left salpingo-oophorectomy that confirmed the diagnosis of a unilateral Leydig cell tumor. Complete normalization of androgens and gonadotropin levels was achieved after surgery.

引用

页码：240 / 245

页数：6

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