Association of Leptin Gene Polymorphisms with Litter Performance Traits in Four Chinese Indigenous Pig Breeds

被引：0

作者：

Ding, Xiaoling ^{[1
]}

Yan, Yan ^{[1
]}

Zhang, Chenghua ^{[1
]}

Ding, Yueyun ^{[1
]}

Yin, Zongjun ^{[1
]}

机构：

[1] Anhui Agr Univ, Dept Anim Sci, Coll Anim Sci & Technol, Hefei 230036, Peoples R China

来源：

JOURNAL OF ANIMAL AND VETERINARY ADVANCES | 2011年 / 10卷 / 05期

关键词：

Pig; PCR-SSCP; association; leptin gene; SNP; litter performance traits; China; EXPRESSION; RECEPTOR; LOCALIZATION; FATNESS;

D O I：

暂无

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

In this study, leptin gene was chosen as a candidate gene to evaluate its effect on litter performance traits in four indigenous pig population of Anhui province in China. Two SNPs (U_66254 g.3469 T>C; g. 371 4 G>T) in Exon 3 of leptin gene were demonstrated by PCR-SSCP and sequencing of PCR product. Litter performance traits including Numbers of Born Alive (NBA) of the first parity and latter parities were recorded in four pig breeds population. The further association analysis of the 2 SNPs with litter performance traits were conducted in four pig breeds population including 213 sows. Researchers found the 2 SNPs are significantly associated with litter performance traits. The effect of CC genotype of SNP (U_66254 g.3469 T>C) and TT genotype of SNP (U_66254 g.3714 G>T) were significantly higher than other genotypes in both litter traits (p<0.05). The study suggested that lepetin gene could be used for marker assisted selection program as a molecular genetic marker for litter sizes in Chinese indigenous pig breeding.

引用

页码：663 / 667

页数：5

共 18 条

[1] Cloning and expression of the porcine obese gene [J].

Bidwell, CA ;

Ji, SQ ;

Frank, GR ;

Cornelius, SG ;

Willis, GM ;

Spurlock, ME .

ANIMAL BIOTECHNOLOGY, 1997, 8 (02) :191-206

[2] RECOMBINANT MOUSE OB PROTEIN - EVIDENCE FOR A PERIPHERAL SIGNAL LINKING ADIPOSITY AND CENTRAL NEURAL NETWORKS [J].

CAMPFIELD, LA ;

SMITH, FJ ;

GUISEZ, Y ;

DEVOS, R ;

BURN, P .

SCIENCE, 1995, 269 (5223) :546-549

[3] A synonymous SNP of the corneodesmosin gene leads to increased mRNA stability and demonstrates association with psoriasis across diverse ethnic groups [J].

Capon, F ;

Allen, MH ;

Ameen, M ;

Burden, AD ;

Tillman, D ;

Barker, JN ;

Trembath, RC .

HUMAN MOLECULAR GENETICS, 2004, 13 (20) :2361-2368

[4] Genetic polymorphisms in porcine leptin gene and their association with reproduction and production traits [J].

Chen, CC ;

Chang, T ;

Su, HY .

AUSTRALIAN JOURNAL OF AGRICULTURAL RESEARCH, 2004, 55 (06) :699-704

[5] Associations of leptin gene polymorphisms with production traits in pigs [J].

de Oliveira Peixoto, J. ;

Guimaraes, S. E. Facioni ;

Lopes, P. Savio ;

Soares, M. A. Menck ;

Pires, A. Vieira ;

Barbosa, M. V. Gualberto ;

de Almeida Torres, R. ;

e Silva, M. de Almeida .

JOURNAL OF ANIMAL BREEDING AND GENETICS, 2006, 123 (06) :378-383

[6] A polymorphism in the 5′ untranslated region of the human ob gene is associated with low leptin levels [J].

Hager, J ;

Clement, K ;

Francke, S ;

Raison, J ;

Lahlou, N ;

Rich, N ;

Pelloux, V ;

Basdevant, A ;

Guy-Grand, B ;

North, M ;

Froguel, P .

INTERNATIONAL JOURNAL OF OBESITY, 1998, 22 (03) :200-205

[7] Regulation of energy balance by leptin [J].

Hamann, A ;

Matthaei, S .

EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES, 1996, 104 (04) :293-300

[8] Genetic polymorphisms in the leptin gene and their association with fatness in four pig breeds [J].

Jiang, ZH ;

Gibson, JP .

MAMMALIAN GENOME, 1999, 10 (02) :191-193

[9] Leptin and leptin receptor expression in rat and mouse pituitary cells [J].

Jin, L ;

Zhang, S ;

Burguera, BG ;

Couce, ME ;

Osamura, RY ;

Kulig, E ;

Lloyd, RV .

ENDOCRINOLOGY, 2000, 141 (01) :333-339

[10] Characterization of swine leptin (LEP) polymorphisms and their association with production traits [J].

Kennes, YM ;

Murphy, BD ;

Pothier, F ;

Palin, MF .

ANIMAL GENETICS, 2001, 32 (04) :215-218

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