Significance of MPV, RDW and PDW with the Severity and Mortality of COVID-19 and Effects of Acetylsalicylic Acid Use

被引：13

作者：

Aydinyilmaz, Faruk ^{[1
]}

Aksakal, Emrah ^{[1
]}

Pamukcu, Hilal Erken ^{[2
]}

Aydemir, Selim ^{[3
]}

Dogan, Remziye ^{[4
]}

Sarac, Ibrahim ^{[1
]}

Aydin, Sidar Siyar ^{[5
]}

Kalkan, Kamuran ^{[1
]}

Gulcu, Oktay ^{[1
]}

Tanboga, Ibrahim Halil ^{[6
]}

机构：

[1] Univ Hlth Sci, Erzurum Educ & Res Hosp, Erzurum, Turkey

[2] Univ Hlth Sci, Diskapi Yildirim Beyazit Educ & Res Hosp, Ankara, Turkey

[3] Marasal Cakmak State Hosp, Erzurum, Turkey

[4] Horasan State Hosp, Erzurum, Turkey

[5] Dogubeyazit State Hosp, Agri, Turkey

[6] Nisantasi Univ, Hisar Intercontinental Hosp, Istanbul, Turkey

来源：

CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS | 2021年 / 27卷

关键词：

mean platelet volume; platelet distribution width; red cell distribution width; COVID-19; MEAN PLATELET VOLUME; CELL DISTRIBUTION WIDTH; COUNT; RISK;

D O I：

10.1177/10760296211048808

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We aimed to investigate association between mean platelet volume (MVP), platelet distribution width (PDW) and red cell distribution width (RDW) and mortality in patients with COVID-19 and find out in which patients the use of acetylsalicylic acid (ASA) affects the prognosis due to the effect of MPV on thromboxan A2. A total of 5142 patients were divided into those followed in the intensive care unit (ICU) and those followed in the ward. Patient medical records were examined retrospectively. ROC analysis showed that the area under curve (AUC) values were 0.714, 0.750, 0.843 for MPV, RDW and D-Dimer, the cutoff value was 10.45fl, 43.65fl, 500.2 ng/mL respectively. (all P < .001). Survival analysis showed that patients with MPV >10.45 f/l and D-Dimer >500.2 ng/mL, treatment with ASA had lower in-hospital and 180-day mortality than patients without ASA in ICU patients (HR = 0.773; 95% CI = 0.595-0.992; P = .048, HR = 0.763; 95% CI = 0.590-0.987; P = .036). Administration of low-dose ASA in addition to anti-coagulant according to MPV and D-dimer levels reduces mortality.

引用

页数：8

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