Residual microcalcifications after neoadjuvant chemotherapy for locally advanced breast cancer: comparison of the accuracies of mammography and MRI in predicting pathological residual tumor

被引:15
作者
An, Yeong Yi [1 ]
Kim, Sung Hun [2 ]
Kang, Bong Joo [2 ]
机构
[1] Catholic Univ Korea, St Vincents Hosp, Dept Radiol, Coll Med, 93 Jungbu Daero, Suwon, Gyeonggi Do, South Korea
[2] Catholic Univ Korea, Seoul St Marys Hosp, Dept Radiol, Coll Med, 222 Banpo Daero, Seoul 06591, South Korea
关键词
PREOPERATIVE CHEMOTHERAPY; CLINICAL EXAMINATION; COMPLETE RESPONSE; SONOGRAPHY; WOMEN; CALCIFICATIONS; DISEASE;
D O I
10.1186/s12957-017-1263-8
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: The aims of this study were to correlate residual mammographic microcalcifications after neoadjuvant chemotherapy (NAC) with pathological results and to compare the accuracy of mammography (MG) and magnetic resonance imaging (MRI) in predicting the size of residual tumors. Methods: The imaging findings and pathological results for 29 patients with residual microcalcifications after NAC were reviewed. We compared the agreement of the measured extent of residual microcalcifications based on MG and residual enhancement based on MRI with the residual tumor size based on pathology. Results: At final pathology, residual microcalcifications were malignant in 55.2% of cases and benign in 44.8% of cases. In 36% of non-pCR cases, the remaining microcalcifications were benign. Compared with the measurements of residual tumor obtained from pathology, MG showed poor agreement, and MRI showed moderate agreement, for the entire group (concordance correlation coefficient [CCC] = 0.196 vs. 0.566). Regarding the receptor status, the agreement of measurements obtained by MG was superior to that obtained by MRI (CCC = 0.5629, 0.5472 vs. 0.4496, 0.4279) for ER(+) and HER2(-) tumors. In ER(-) tumors, the measurements obtained by MG showed the lowest agreement with the pathological tumor size, which had the highest agreement with those obtained by MRI (CCC = - 0.0162 vs. 0.8584). Conclusions: Residual mammographic microcalcifications after NAC did not correlate with malignancy in 44.8% of cases. Residual microcalcifications on MG were poorly correlated with pathological tumor size, and MRI might be more reliable for predicting residual tumor size after NAC. Tumor receptor status affected the accuracy of both MG and MRI for predicting residual tumor size after NAC.
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页数:7
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