Transdermal Delivery of Luteinizing Hormone-releasing Hormone with Chitosan Microneedles: A Promising Tool for Androgen Deprivation Therapy

被引:25
作者
Chen, Ming-Yang [1 ]
Chen, Yi-Ying [2 ]
Tsai, Hsin-Tzu [3 ]
Tzai, Tzong-Shin [4 ,5 ]
Chen, Mei-Chin [2 ]
Tsai, Yuh-Shyan [3 ]
机构
[1] Madou Sin Lau Hosp, Sin Lau Med Fdn, Presbyterian Church Taiwan, Dept Urol, Tainan, Taiwan
[2] Natl Cheng Kung Univ, Dept Chem Engn, Tainan 70101, Taiwan
[3] Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Dept Urol, Coll Med, 138 Sheng Li Rd, Tainan 70403, Taiwan
[4] China Med Univ, Sch Med, Dept Urol, Taichung, Taiwan
[5] China Med Univ, An Nan Hosp, Dept Urol, Tainan, Taiwan
关键词
Prostate cancer; testosterone; microneedle; chitosan; RESISTANT PROSTATE-CANCER; ESTRO-SIOG GUIDELINES; DRUG-DELIVERY; CASTRATION; INSULIN; VACCINATION; STATISTICS; ABSORPTION; MECHANISM; DIAGNOSIS;
D O I
10.21873/anticanres.12139
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Long-term administration of luteinizing hormone-releasing hormone analogs (LHRHa) is the main type of androgen-deprivation therapy (ADT) for lethal prostate cancer. A fully insertable microneedle system, composed of embeddable chitosan microneedles and a dissolvable polyvinyl alcohol/polyvinyl pyrrolidone supporting array, was developed for sustained delivery of LHRHa to the skin. A porcine cadaver skin test showed that chitosan microneedles can be fully embedded within the skin and microneedle-created micropores reseal within 7 days. The measured LHRHa loading amount was 73.3 +/- 2.8 mu g per microneedle patch. After applying goserelin-containing microneedles to mice, serum LH levels increased initially and then declined below baseline at day 7. In contrast, serum testosterone levels increased to reach a peak at day 14 and then declined to a castration level at day 21. Additionally, such a castration level was maintained for 2 weeks. Therefore, transdermal delivery of goserelin with embeddable chitosan microneedles can produce a castrated state in mice. Such a system is a promising, feasible means of delivering ADT.
引用
收藏
页码:6791 / 6797
页数:7
相关论文
共 30 条
[1]   Fully embeddable chitosan microneedles as a sustained release depot for intradermal vaccination [J].
Chen, Mei-Chin ;
Huang, Shih-Fang ;
Lai, Kuan-Ying ;
Ling, Ming-Hung .
BIOMATERIALS, 2013, 34 (12) :3077-3086
[2]   EAU-ESTRO-SIOG Guidelines on Prostate Cancer. Part II: Treatment of Relapsing, Metastatic, and Castration-Resistant Prostate Cancer [J].
Cornford, Philip ;
Bellmunt, Joaquim ;
Bolla, Michel ;
Briers, Erik ;
De Santis, Maria ;
Gross, Tobias ;
Henry, Ann M. ;
Joniau, Steven ;
Lam, Thomas B. ;
Mason, Malcolm D. ;
van der Poel, Henk G. ;
van der Kwast, Theo H. ;
Rouviere, Olivier ;
Wiegel, Thomas ;
Mottet, Nicolas .
EUROPEAN UROLOGY, 2017, 71 (04) :630-642
[3]   Noninfective cutaneous granuloma with leuprorelin acetate - Reality or myth [J].
Dangle, Pankaj ;
Palit, Victor ;
Sundaram, S. K. ;
Weston, Philip .
UROLOGY, 2007, 69 (04) :779.e5-779.e6
[4]   Transdermal drug delivery by coated microneedles: Geometry effects on effective skin thickness and drug permeability [J].
Davidson, Adam ;
Al-Qallaf, Barrak ;
Das, Diganta Bhusan .
CHEMICAL ENGINEERING RESEARCH & DESIGN, 2008, 86 (11A) :1196-1206
[5]   Studies on prostate cancer II The effects of castration on advanced carcinoma of the prostate gland [J].
Huggins, C ;
Stevens, RE ;
Hodges, CV .
ARCHIVES OF SURGERY, 1941, 43 (02) :209-223
[6]   Feasibility of microneedles for percutaneous absorption of insulin [J].
Ito, Yukako ;
Hagiwara, Eiji ;
Saeki, Atsushi ;
Sugioka, Nobuyuki ;
Takada, Kanji .
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2006, 29 (01) :82-88
[7]   Biodegradation, biodistribution and toxicity of chitosan [J].
Kean, T. ;
Thanou, M. .
ADVANCED DRUG DELIVERY REVIEWS, 2010, 62 (01) :3-11
[8]   The effect of the degree of chitosan deacetylation on the efficiency of gene transfection [J].
Kiang, T ;
Wen, H ;
Lim, HW ;
Leong, KW .
BIOMATERIALS, 2004, 25 (22) :5293-5301
[9]   Combined tamoxifen and luteinizing hormone-releasing hormone (LHRH) agonist versus LHRH agonist alone in premenopausal advanced breast cancer: A meta-analysis of four randomized trials [J].
Klijn, JGM ;
Blamey, RW ;
Boccardo, F ;
Tominaga, T ;
Duchateau, L ;
Sylvester, R .
JOURNAL OF CLINICAL ONCOLOGY, 2001, 19 (02) :343-353
[10]   Nanoglycan Complex Formulation Extends VEGF Retention Time in the Lung [J].
Lauten, E. Hunter ;
VerBerkmoes, Jarod ;
Choi, Justin ;
Jin, Richard ;
Edwards, David A. ;
Loscalzo, Joseph ;
Zhang, Ying-Yi .
BIOMACROMOLECULES, 2010, 11 (07) :1863-1872