RETRACTED: Down-regulation of microRNA-342-5p or Up-regulation of Wnt3a Inhibits Angiogenesis and Maintains Atherosclerotic Plaque Stability in Atherosclerosis Mice (Retracted article. See vol. 18, 2023)

被引:13
作者
Sun, Haixia [1 ]
Feng, Jinhua [2 ]
Ma, Yan [3 ]
Cai, Ding [4 ]
Luo, Yulu [1 ]
Wang, Qinggong [1 ]
Li, Fang [1 ]
Zhang, Mingyue [1 ]
Hu, Quanzhong [4 ]
机构
[1] Qinghai Prov Peoples Hosp, Dept Cardiac Ultrasound, Xining 810007, Qinghai, Peoples R China
[2] Qinghai Prov Peoples Hosp, Dept Gen Practitioner, Xining 810007, Qinghai, Peoples R China
[3] Haixi Peoples Hosp, Dept Cardiac Ultrasound, Delingha 817099, Qinghai, Peoples R China
[4] Qinghai Prov Peoples Hosp, Dept Neurol, 2 Gonghe Rd, Xining 810007, Qinghai, Peoples R China
来源
NANOSCALE RESEARCH LETTERS | 2021年 / 16卷 / 01期
关键词
Atherosclerosis; MicroRNA-342-5p; Wnt3a; Vulnerable plaque; Vulnerability index; Microvessel density; CELLS; HYPERLIPIDEMIA; PROLIFERATION; EXPRESSION; MIGRATION; INJURY;
D O I
10.1186/s11671-021-03608-w
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
Evidence has demonstrated that microRNA-342-5p (miR-342-5p) is implicated in atherosclerosis (AS), but little is known regarding its intrinsic regulatory mechanisms. Here, we aimed to explore the effect of miR-342-5p targeting Wnt3a on formation of vulnerable plaques and angiogenesis of AS. ApoE(-/-) mice were fed with high-fat feed for 16 w to replicate the AS vulnerable plaque model. miR-342-5p and Wnt3a expression in aortic tissues of AS were detected. The target relationship between miR-342-5p and Wnt3a was verified. Moreover, ApoE(-/-) mice were injected with miR-342-5p antagomir and overexpression-Wnt3a vector to test their functions in serum lipid levels, inflammatory and oxidative stress-related cytokines, aortic plaque stability and angiogenesis in plaque of AS mice. miR-342-5p expression was enhanced and Wnt3a expression was degraded in aortic tissues of AS mice and miR-342-5p directly targeted Wnt3a. Up-regulating Wnt3a or down-regulating miR-342-5p reduced blood lipid content, inflammatory and oxidative stress levels, the vulnerability of aortic tissue plaque and inhibited angiogenesis in aortic plaque of AS mice. Functional studies show that depleting miR-342-5p can stabilize aortic tissue plaque and reduce angiogenesis in plaque in AS mice via restoring Wnt3a.
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页数:13
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