Diabetes, microvascular complications, and cardiovascular complications: what is it about glucose? Commentary

被引：110
作者：
Reusch, JEB
机构：
[1] Vet Affairs Med Ctr, Endocrinol Sect 111H, Denver, CO 80220 USA
[2] Univ Colorado, Hlth Sci Ctr, Div Endocrinol Diabet & Metab, Dept Med, Denver, CO USA
来源：
JOURNAL OF CLINICAL INVESTIGATION | 2003年 / 112卷 / 07期
关键词：
D O I：
10.1172/JCI200319902
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Glycemic control is the primary mediator of diabetic microvascular complications and also contributes to macrovascular complications. A new study (see related article beginning on page 1049) reveals a previously unrecognized association between oxidant activation of poly(ADP ribose) polymerase (PARP) and upregulation of known mediators of glycemic injury. Inhibitors of PARP may have potential therapeutic roles in the prevention of diabetic complications.
引用
收藏
页码：986 / 988
页数：3
相关论文
共 32 条
  • [1] Relationship between obesity, insulin resistance, and coronary heart disease risk
    Abbasi, F
    Brown, BW
    Lamendola, C
    McLaughlin, T
    Reaven, GM
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2002, 40 (05) : 937 - 943
  • [2] The sensory symptoms of diabetic polyneuropathy are improved with α-lipoic acid -: The SYDNEY trial
    Ametov, AS
    Barinov, A
    Dyck, PJ
    Hermann, R
    Kozlova, N
    Litchy, WJ
    Low, PA
    Nehrdich, D
    Novosadova, M
    O'Brien, PC
    Reljanovic, M
    Samigullin, R
    Schuette, K
    Strokov, I
    Tritschler, H
    Wessel, K
    Yakhno, N
    Ziegler, D
    [J]. DIABETES CARE, 2003, 26 (03) : 770 - 776
  • [3] Estimated number of adults with prediabetes in the US in 2000 - Opportunities for prevention
    Benjamin, SM
    Valdez, R
    Geiss, LS
    Rolka, DB
    Narayan, KMV
    [J]. DIABETES CARE, 2003, 26 (03) : 645 - 649
  • [4] Projection of diabetes burden through 2050 - Impact of changing demography and disease prevalence in the US
    Boyle, JP
    Honeycutt, AA
    Narayan, KMV
    Hoerger, TJ
    Geiss, LS
    Chen, H
    Thompson, TJ
    [J]. DIABETES CARE, 2001, 24 (11) : 1936 - 1940
  • [5] Biochemistry and molecular cell biology of diabetic complications
    Brownlee, M
    [J]. NATURE, 2001, 414 (6865) : 813 - 820
  • [6] Collins R, 2003, LANCET, V361, P2005
  • [7] POSTCHALLENGE GLUCOSE-CONCENTRATION AND CORONARY HEART-DISEASE IN MEN OF JAPANESE ANCESTRY - HONOLULU HEART PROGRAM
    DONAHUE, RP
    ABBOTT, RD
    REED, DM
    YANO, K
    [J]. DIABETES, 1987, 36 (06) : 689 - 692
  • [8] Du XL, 2003, J CLIN INVEST, V112, P1049, DOI 10.1172/JCI200318127
  • [9] Evans J L, 2000, Diabetes Technol Ther, V2, P401, DOI 10.1089/15209150050194279
  • [10] Gerstein HC, 2000, LANCET, V355, P253
1234