Cell-Penetrating Peptides: a Useful Tool for the Delivery of Various Cargoes Into Cells

被引：85

作者：

Bohmova, E. ^{[1
]}

Machova, D. ^{[1
]}

Pechar, M. ^{[1
]}

Pola, R. ^{[1
]}

Venclikova, K. ^{[1
]}

Janouskova, O. ^{[1
]}

Etrych, T. ^{[1
]}

机构：

[1] Czech Acad Sci, Inst Macromol Chem, Prague, Czech Republic

来源：

PHYSIOLOGICAL RESEARCH | 2018年 / 67卷

关键词：

Cell-penetrating peptides; Cell penetration; Peptides; Drug delivery; NUCLEAR-LOCALIZATION SIGNALS; MEMBRANE-PERMEABLE PEPTIDES; NF-KAPPA-B; IN-VIVO; ANTIMICROBIAL PEPTIDE; PLASMA-MEMBRANE; SIRNA DELIVERY; RICH PEPTIDES; BASIC DOMAIN; TAT PROTEIN;

D O I：

10.33549/physiolres.933975

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Cell-penetrating compounds are substances that enhance the cellular uptake of various molecular cargoes that do not easily cross the cellular membrane. The majority of cell-penetrating compounds described in the literature are cell-penetrating peptides (CPPs). This review summarizes the various structural types of cell-penetrating compounds, with the main focus on CPPs. The authors present a brief overview of the history of CPPs, discuss the various types of conjugation of CPPs to biologically active cargoes intended for cell internalization, examine the cell-entry mechanisms of CPPs, and report on the applications of CPPs in research and in preclinical and clinical studies.

引用

页码：S267 / S279

页数：13

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