Characterization of 9 gas chromatography columns by Kovats and Lee retention indices for dioxin analysis

被引:6
作者
Stultz, Conner [1 ]
Dorman, Frank [2 ]
机构
[1] Penn State Univ, Dept Chem, 109 Chem Bldg, University Pk, PA 16802 USA
[2] Penn State Univ, Dept Biochem Microbiol & Mol Biol, 107 Althouse Lab, University Pk, PA 16802 USA
关键词
Retention indices; GC-MS; Dioxins and furans; Column selectivity; Column orthogonality; DIBENZO-P-DIOXINS; SPECTROMETRY; FURANS;
D O I
10.1016/j.chroma.2019.460701
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Polychlorinated dibenzo-p-dioxins and furans offer a complex separation challenge due to their chemical similarity and 5020 possible congeners, including the Br/CI congeners. Not only are these compounds difficult to separate, but they are also difficult to identify. Expensive reference materials are needed for conventional "dioxin analysis", usually requiring C-13 labeled and native compounds. A retention index database offers a potential solution to lower the difficulty and cost to identify dioxins. This study describes the use of Kovats and Lee retention indices for the identification of chlorinated dioxins and furans as well as their brominated and mixed chloroibromo counterparts. Eight columns were characterized with all 136 tetra through octa substituted chlorinated dioxins and furans as well as 32 brominated and mixed chloroibromo congeners. Columns were then compared to identify which stationary phases provided the best resolution for critical congeners, like the 2,3,7,8 substituted compounds. Column phase selectivity was also investigated to identify best commercially-available column pairings for confirmatory analyses and GC x GC separations. The Rtx-Dioxin2 and Rxi-17SilMS showed unique selectivity for dioxins and furans and could be used as confirmatory columns or as a powerful GC x GC column set. (C) 2019 Published by Elsevier B.V.
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页数:12
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