Shared genetic and epigenetic changes link aging and cancer

被引：29
|
作者：
Zabransky, Daniel J. [1 ,2 ]
Jaffee, Elizabeth M. [1 ,2 ]
Weeraratna, Ashani T. [1 ,3 ]
机构：
[1] Johns Hopkins Univ, Sidney Kimmel Comprehens Canc Ctr, Dept Oncol, Sch Med, Baltimore, MD 21287 USA
[2] Johns Hopkins Univ, Bloomberg Kimmel Inst Canc Immunotherapy, Sch Med, Baltimore, MD 21287 USA
[3] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Biochem & Mol Biol, Baltimore, MD 21287 USA
来源：
TRENDS IN CELL BIOLOGY | 2022年 / 32卷 / 04期
关键词：
HISTONE VARIANT H3.3; STRAND BREAK REPAIR; SOMATIC MUTATIONS; LIFE-SPAN; CLONAL HEMATOPOIESIS; GENOMIC INSTABILITY; AGE; CHROMATIN; EXPRESSION; SIRT6;
D O I：
10.1016/j.tcb.2022.01.004
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Aging is a universal biological process that increases the risk of multiple diseases including cancer. Growing evidence shows that alterations in the genome and epigenome, driven by similar mechanisms, are found in both aged cells and cancer cells. In this review, we detail the genetic and epigenetic changes associated with normal aging and the mechanisms responsible for these changes. By highlighting genetic and epigenetic alterations in the context of tumorigenesis, cancer progression, and the aging tumor microenvironment, we examine the possible impacts of the normal aging process on malignant transformation. Finally, we examine the implications of age-related genetic and epigenetic alterations in both tumors and patients for the treatment of cancer.
引用
收藏
页码：338 / 350
页数：13
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