STAT-3 correlates with lymph node metastasis and cell survival in gastric cancer

被引：86
作者：
Deng, Jing-Yu [1 ,2 ]
Sun, Dan [3 ]
Liu, Xiang-Yu [1 ,2 ]
Pan, Yi [4 ]
Liang, Han [1 ,2 ]
机构：
[1] Tianjin Med Univ, Dept Gastr, Canc Hosp, Div Oncol, Tianjin 300060, Peoples R China
[2] Tianjin Canc Ctr, City Key Lab, Tianjin 300060, Peoples R China
[3] Tianjin Med Univ, Lung Canc Inst, Gen Hosp, Tianjin 300060, Peoples R China
[4] Tianjin Med Univ, Dept Pathol, Canc Hosp, Tianjin 300060, Peoples R China
来源：
WORLD JOURNAL OF GASTROENTEROLOGY | 2010年 / 16卷 / 42期
关键词：
Gastric cancer; Signal transducer and activator of transcription-3; Lymph node metastasis; Apoptosis; Survival analysis; ACTIVATED SIGNAL TRANSDUCER; POOR-PROGNOSIS; GROWTH-FACTOR; EXPRESSION; CARCINOMA; SOCS-1; METHYLATION; INHIBITION; SUPPRESSOR; PHENOTYPE;
D O I：
10.3748/wjg.v16.i42.5380
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
AIM: To investigate the correlation between gastric cancer growth and signal transducer and activator of transcription-3 (STAT3) expression. METHODS: We assessed the expressions of STAT3, phosphor-STAT3 (pSTAT3), suppressor of cytokine signaling-1 (SOCS-1), survivin and Bcl-2 in gastric cancer patients after gastrectomy by immunohistochemical method. In addition, in situ hybridization was used to further demonstrate the mRNA expression of STAT3 in gastric cancer. RESULTS: With the univariate analysis, expressions of STAT3, pSTAT3, SOCS-1, survivin and Bcl-2, the size of primary tumor and the lymph node metastasis were found to be associated with the overall survival (OS) of gastric cancer patients. However, only pSTAT3 expression and the lymph node metastasis were identified as the independent factors of OS of gastric cancer with multivariate analysis. STAT3 expression was correlated with the lymph node metastasis. There were positive correlations between expressions of STAT3, survivin, Bcl-2 and pSTAT3 in gastric cancer, whereas there was negative correlation between STAT3 expression and SOCS-1 expression in gastric cancer. CONCLUSION: STAT3 can transform into pSTAT3 to promote the survival and inhibit the apoptosis of gastric cancer cells. SOCS-1 might be the valid molecular antagonist to inhibit the STAT3 expression in gastric cancer. (C) 2010 Baishideng. All rights reserved.
引用
收藏
页码：5380 / 5387
页数：8
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