A Novel Trypsin-Catalyzed Three-Component Mannich Reaction

被引：31

作者：

Chai, She-Jie ^{[1
]}

Lai, Yi-Feng ^{[1
]}

Zheng, Hui ^{[1
]}

Zhang, Peng-Fei ^{[1
]}

机构：

[1] Hangzhou Normal Univ, Coll Mat Chem & Chem Engn, Hangzhou 310036, Zhejiang, Peoples R China

来源：

HELVETICA CHIMICA ACTA | 2010年 / 93卷 / 11期

关键词：

ANTARCTICA LIPASE-B; BETA-AMINO; ALCOHOLS;

D O I：

10.1002/hlca.201000063

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We found that the trypsin from hog pancreas displayed high activity to promote three component Mannich reaction of aromatic aldehydes, aromatic amines, and acetone with moderate-to-excellent yields. The reaction tolerates a great range of substrates and extends the application of trypsin in organic synthesis.

引用

页码：2231 / 2236

页数：6

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