Novel H5 clade 2.3.4.6 viruses with both α-2,3 and α-2,6 receptor binding properties may pose a pandemic threat

被引：30

作者：

Li, Qunhui ^{[1
]}

Wang, Xuan ^{[1
]}

Gu, Min ^{[1
,2
]}

Zhu, Jie ^{[1
]}

Hao, Xiaoli ^{[1
]}

Gao, Zhao ^{[1
]}

Sun, Zhongtao ^{[1
]}

Hu, Jiao ^{[1
,2
]}

Hu, Shunlin ^{[1
,2
]}

Wang, Xiaoquan ^{[1
,2
]}

Liu, Xiaowen ^{[1
,2
]}

Liu, Xiufan ^{[1
,2
]}

机构：

[1] Yangzhou Univ, Coll Vet Med, Anim Infect Dis Lab, Yangzhou 225009, Jiangsu, Peoples R China

[2] Jiangsu Coinnovat Ctr Prevent & Control Important, Yangzhou 225009, Jiangsu, Peoples R China

来源：

VETERINARY RESEARCH | 2014年 / 45卷

基金：

中国国家自然科学基金;

关键词：

AVIAN INFLUENZA-VIRUSES; EASTERN CHINA;

D O I：

10.1186/s13567-014-0127-2

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

The emerging H5 clade 2.3.4.6 viruses of different NA subtypes have been detected in different domestic poultry in China. We evaluated the receptor binding property and transmissibility of four novel H5 clade 2.3.4.6 subtype highly pathogenic avian influenza viruses. The results show that these viruses bound to both avian-type (alpha-2,3) and human-type (alpha-2,6) receptors. Furthermore, we found that one of these viruses, GS/EC/1112/11, not only replicated but also transmitted efficiently in guinea pigs. Therefore, such novel H5 subtype viruses have the potential of a pandemic threat.

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