The Role of TDP-43 in Alzheimer's Disease

被引：72

作者：

Chang, Xiao-Long ^{[1
]}

Tan, Meng-Shan ^{[2
]}

Tan, Lan ^{[1
,2
]}

Yu, Jin-Tai ^{[2
,3
]}

机构：

[1] Dalian Med Univ, Qingdao Municipal Hosp, Dept Neurol, Qingdao, Peoples R China

[2] Qingdao Univ, Sch Med, Qingdao Municipal Hosp, Dept Neurol, Qingdao 266071, Peoples R China

[3] Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA USA

来源：

MOLECULAR NEUROBIOLOGY | 2016年 / 53卷 / 05期

基金：

中国国家自然科学基金;

关键词：

TDP-43; A beta; Tau; Alzheimer's disease; Pathogenesis; Therapy; AMYOTROPHIC-LATERAL-SCLEROSIS; TAR-DNA-BINDING; FRONTOTEMPORAL LOBAR DEGENERATION; MOTOR-NEURON DISEASE; MOUSE MODEL; PROTEIN; 43; MITOCHONDRIAL DYSFUNCTION; TRANSGENIC MICE; NEURODEGENERATIVE DISEASES; PARKINSONS-DISEASE;

D O I：

10.1007/s12035-015-9264-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The transactive response DNA binding protein (TDP-43) has long been characterized as a main hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U, also known as FTLD-TDP). Several studies have indicated TDP-43 deposits in Alzheimer's disease (AD) brains and have robust connection with AD clinical phenotype. FTLD-U, which was symptomatically connected with AD, may be predictable for the comprehension of the role TDP-43 in AD. TDP-43 may contribute to AD through both beta-amyloid (A beta)-dependent and A beta-independent pathways. In this article, we summarize the latest studies concerning the role of TDP-43 in AD and explore TDP-43 modulation as a potential therapeutic strategy for AD. However, to date, little of pieces of the research on TDP-43 have been performed to investigate the role in AD; more investigations need to be confirmed in the future.

引用

页码：3349 / 3359

页数：11

共 91 条

[61] TAR-DNA binding protein-43 and alterations in the hippocampus [J].

Rauramaa, Tuomas ;

Pikkarainen, Maria ;

Englund, Elisabet ;

Ince, Paul G. ;

Jellinger, Kurt ;

Paetau, Anders ;

Alafuzoff, Irina .

JOURNAL OF NEURAL TRANSMISSION, 2011, 118 (05) :683-689

[62] TARDBP mutations in Parkinson's disease [J].

Rayaprolu, Sruti ;

Fujioka, Shinsuke ;

Traynor, Sharleen ;

Soto-Ortolaza, Alexandra I. ;

Petrucelli, Leonard ;

Dickson, Dennis W. ;

Rademakers, Rosa ;

Boylan, Kevin B. ;

Graff-Radford, Neill R. ;

Uitti, Ryan J. ;

Wszolek, Zbigniew K. ;

Ross, Owen A. .

PARKINSONISM & RELATED DISORDERS, 2013, 19 (03) :312-315

[63] BETA-AMYLOID PROTEIN DEPOSITION IN THE BRAIN AFTER SEVERE HEAD-INJURY - IMPLICATIONS FOR THE PATHOGENESIS OF ALZHEIMERS-DISEASE [J].

ROBERTS, GW ;

GENTLEMAN, SM ;

LYNCH, A ;

MURRAY, L ;

LANDON, M ;

GRAHAM, DI .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1994, 57 (04) :419-425

[64] No interaction between tau and TDP-43 pathologies in either frontotemporal lobar degeneration or motor neurone disease [J].

Robinson, A. C. ;

Thompson, J. C. ;

Weedon, L. ;

Rollinson, S. ;

Pickering-Brown, S. ;

Snowden, J. S. ;

Davidson, Y. S. ;

Mann, D. M. A. .

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 2014, 40 (07) :844-854

[65] Caspase-cleaved TAR DNA-binding protein-43 is a major pathological finding in Alzheimer's disease [J].

Rohn, Troy T. .

BRAIN RESEARCH, 2008, 1228 :189-198

[66] Evolutionarily Conserved Heterogeneous Nuclear Ribonucleoprotein (hnRNP) A/B Proteins Functionally Interact with Human and Drosophila TAR DNA-binding Protein 43 (TDP-43) [J].

Romano, Maurizio ;

Buratti, Emanuele ;

Romano, Giulia ;

Klima, Raffaella ;

Belluz, Lisa Del Bel ;

Stuani, Cristiana ;

Baralle, Francisco ;

Feiguin, Fabian .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2014, 289 (10) :7121-7130

[67] Mitochondrial Ca2+ Overload Underlies Aβ Oligomers Neurotoxicity Providing an Unexpected Mechanism of Neuroprotection by NSAIDs [J].

Sanz-Blasco, Sara ;

Valero, Ruth A. ;

Rodriguez-Crespo, Ignacio ;

Villalobos, Carlos ;

Nunez, Lucia .

PLOS ONE, 2008, 3 (07)

[68] Alterations in subcellular localization of TDP-43 immunoreactivity in the anterior horns in sporadic amyotrophic lateral sclerosis [J].

Sasaki, Shoichi ;

Takeda, Takahiro ;

Shibata, Noriyuki ;

Kobayashi, Makio .

NEUROSCIENCE LETTERS, 2010, 478 (02) :72-76

[69] Is synaptic loss a unique hallmark of Alzheimer's disease? [J].

Scheff, Stephen W. ;

Neltner, Janna H. ;

Nelson, Peter T. .

BIOCHEMICAL PHARMACOLOGY, 2014, 88 (04) :517-528

[70] Inhibition of γ-secretase activity reduces Aβ production, reduces oxidative stress, increases mitochondrial activity and leads to reduced vulnerability to apoptosis: Implications for the treatment of Alzheimer's disease [J].

Sheng, Baiyang ;

Gong, Kai ;

Niu, Ying ;

Liu, Lingling ;

Yan, Yufang ;

Lu, Guangyuan ;

Zhang, Lihai ;

Hu, Min ;

Zhao, Nanming ;

Zhang, Xiufang ;

Tang, Peifu ;

Gong, Yandao .

FREE RADICAL BIOLOGY AND MEDICINE, 2009, 46 (10) :1362-1375

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