The Role of TDP-43 in Alzheimer's Disease

被引：66
作者：
Chang, Xiao-Long [1 ]
Tan, Meng-Shan [2 ]
Tan, Lan [1 ,2 ]
Yu, Jin-Tai [2 ,3 ]
机构：
[1] Dalian Med Univ, Qingdao Municipal Hosp, Dept Neurol, Qingdao, Peoples R China
[2] Qingdao Univ, Sch Med, Qingdao Municipal Hosp, Dept Neurol, Qingdao 266071, Peoples R China
[3] Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA USA
来源：
MOLECULAR NEUROBIOLOGY | 2016年 / 53卷 / 05期
基金：
中国国家自然科学基金;
关键词：
TDP-43; A beta; Tau; Alzheimer's disease; Pathogenesis; Therapy; AMYOTROPHIC-LATERAL-SCLEROSIS; TAR-DNA-BINDING; FRONTOTEMPORAL LOBAR DEGENERATION; MOTOR-NEURON DISEASE; MOUSE MODEL; PROTEIN; 43; MITOCHONDRIAL DYSFUNCTION; TRANSGENIC MICE; NEURODEGENERATIVE DISEASES; PARKINSONS-DISEASE;
D O I：
10.1007/s12035-015-9264-5
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The transactive response DNA binding protein (TDP-43) has long been characterized as a main hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U, also known as FTLD-TDP). Several studies have indicated TDP-43 deposits in Alzheimer's disease (AD) brains and have robust connection with AD clinical phenotype. FTLD-U, which was symptomatically connected with AD, may be predictable for the comprehension of the role TDP-43 in AD. TDP-43 may contribute to AD through both beta-amyloid (A beta)-dependent and A beta-independent pathways. In this article, we summarize the latest studies concerning the role of TDP-43 in AD and explore TDP-43 modulation as a potential therapeutic strategy for AD. However, to date, little of pieces of the research on TDP-43 have been performed to investigate the role in AD; more investigations need to be confirmed in the future.
引用
收藏
页码：3349 / 3359
页数：11
相关论文
共 91 条
  • [31] TDP-43 Regulates Drosophila Neuromuscular Junctions Growth by Modulating Futsch/MAP1B Levels and Synaptic Microtubules Organization
    Godena, Vinay K.
    Romano, Giulia
    Romano, Maurizio
    Appocher, Chiara
    Klima, Raffaella
    Buratti, Emanuele
    Baralle, Francisco E.
    Feiguin, Fabian
    [J]. PLOS ONE, 2011, 6 (03):
  • [32] TDP-43 as a Modulator of Synaptic Plasticity in a Mouse Model of Spinal Motoneuron Degeneration
    Gulino, Rosario
    Forte, Stefano
    Parenti, Rosalba
    Gulisano, Massimo
    [J]. CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS, 2015, 14 (01) : 55 - 60
  • [33] Comparison of Parallel High-Throughput RNA Sequencing Between Knockout of TDP-43 and Its Overexpression Reveals Primarily Nonreciprocal and Nonoverlapping Gene Expression Changes in the Central Nervous System of Drosophila
    Hazelett, Dennis J.
    Chang, Jer-Cherng
    Lakeland, Daniel L.
    Morton, David B.
    [J]. G3-GENES GENOMES GENETICS, 2012, 2 (07): : 789 - 802
  • [34] Wild type TDP-43 induces neuro-inflammation and alters APP metabolism in lentiviral gene transfer models
    Herman, Alexander M.
    Khandelwal, Preeti J.
    Rebeck, G. William
    Moussa, Charbel E. -H.
    [J]. EXPERIMENTAL NEUROLOGY, 2012, 235 (01) : 297 - 305
  • [35] β-Amyloid triggers ALS-associated TDP-43 pathology in AD models
    Herman, Alexander M.
    Khandelwal, Preeti J.
    Stanczyk, Brenna B.
    Rebeck, G. William
    Moussa, Charbel E. -H.
    [J]. BRAIN RESEARCH, 2011, 1386 : 191 - 199
  • [36] Concurrence of TDP-43, tau and α-synuclein pathology in brains of Alzheimer's disease and dementia with Lewy bodies
    Higashi, Shinji
    Iseki, Eizo
    Yamamoto, Ryoko
    Minegishi, Michiko
    Hino, Hiroaki
    Fujisawa, Koshiro
    Togo, Takashi
    Katsuse, Omi
    Uchikado, Hirotake
    Furukawa, Yoshiko
    Kosaka, Kenji
    Arai, Heii
    [J]. BRAIN RESEARCH, 2007, 1184 : 284 - 294
  • [37] TDP-43 associates with stalled ribosomes and contributes to cell survival during cellular stress
    Higashi, Shinji
    Kabuta, Tomohiro
    Nagai, Yoshitaka
    Tsuchiya, Yukihiro
    Akiyama, Haruhiko
    Wada, Keiji
    [J]. JOURNAL OF NEUROCHEMISTRY, 2013, 126 (02) : 288 - 300
  • [38] Hoyert Donna L, 2012, Natl Vital Stat Rep, V61, P1
  • [39] Novel CSF biomarkers for frontotemporal lobar degenerations
    Hu, W. T.
    Chen-Plotkin, A.
    Grossman, M.
    Arnold, S. E.
    Clark, C. M.
    Shaw, L. M.
    McCluskey, L.
    Elman, L.
    Hurtig, H. I.
    Siderowf, A.
    Lee, V. M. -Y.
    Soares, H.
    Trojanowski, J. Q.
    [J]. NEUROLOGY, 2010, 75 (23) : 2079 - 2086
  • [40] Metabolism and mis-metabolism of the neuropathological signature protein TDP-43
    Huang, Chi-Chen
    Bose, Jayarama Krishnan
    Majumder, Pritha
    Lee, Kuen-Haur
    Huang, Jen-Tse Joseph
    Huang, Jeffrey K.
    Shen, Che-Kun James
    [J]. JOURNAL OF CELL SCIENCE, 2014, 127 (14) : 3024 - 3038
12345678910