Molecular modulators of celastrol as the keystones for its diverse pharmacological activities

被引：85

作者：

Ng, Sin Wi ^{[1
]}

Chan, Yinghan ^{[1
]}

Chellappan, Dinesh Kumar ^{[2
]}

Madheswaran, Thiagarajan ^{[3
]}

Zeeshan, Farrukh ^{[3
]}

Chan, Yik Lung ^{[4
]}

Collet, Trudi ^{[5
]}

Gupta, Gaurav ^{[6
]}

Oliver, Brian G. ^{[4
]}

Wark, Peter ^{[7
,8
]}

Hansbro, Nicole ^{[7
,8
]}

Hsu, Alan ^{[7
,8
]}

Hansbro, Philip Michael ^{[7
,8
,9
]}

Dua, Kamal ^{[7
,8
,9
]}

Panneerselvam, Jithendra ^{[3
]}

机构：

[1] IMU, Sch Pharm, Kuala Lumpur 57000, Malaysia

[2] IMU, Sch Pharm, Dept Life Sci, Kuala Lumpur 57000, Malaysia

[3] IMU, Sch Pharm, Dept Pharmaceut Technol, Kuala Lumpur 57000, Malaysia

[4] UTS, Fac Sci, Sch Life Sci, Ultimo, NSW 2007, Australia

[5] QUT, Inst Hlth & Biomed Innovat, Indigenous Med Grp, Brisbane, Qld 4059, Australia

[6] Jaipur Natl Univ, Sch Pharmaceut Sci, Jaipur 302017, Rajasthan, India

[7] Univ Newcastle UoN, HMRI, Prior Res Ctr Hlth Lungs, Callaghan, NSW 2308, Australia

[8] Univ Newcastle UoN, Sch Biomed Sci & Pharm, Callaghan, NSW 2308, Australia

[9] UTS, Grad Sch Hlth, Discipline Pharm, Ultimo, NSW 2007, Australia

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2019年 / 109卷

关键词：

Celastrol; Molecular modulators; Anti-cancer; Anti-inflammatory; Anti-obesity; Neuroprotective; Anti-diabetic; WILFORDII HOOK-F; NF-KAPPA-B; HEAT-SHOCK PROTEINS; SYSTEMIC-LUPUS-ERYTHEMATOSUS; CEREBRAL CORTICAL CULTURES; INSULIN-RESISTANCE; RHEUMATOID-ARTHRITIS; SILVER NANOPARTICLES; AQUEOUS EXTRACT; CROHNS-DISEASE;

D O I：

10.1016/j.biopha.2018.11.051

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

In the recent years, much attention has been focused on identifying bioactive compounds from medicinal plants that could be employed in therapeutics, which is attributed to their potent pharmacological actions and better toxicological profile. One such example that has come into the light with considerable interest is the pentacyclic triterpenoid, celastrol, which has been found to provide substantial therapeutic properties in a variety of diseases. In an effort to further accelerate its potential to be utilized in clinical practice in the future; along with advancing technologies in the field of drug discovery and development, different researchers have been investigating on the various mechanisms and immunological targets of celastrol that underlie its broad spectrum of pharmacological properties. In this review, we have collated the various research findings related to the molecular modulators responsible for different pharmacological activities shown by celastrol. Our review will be of interest to the herbal, biological, molecular scientist and by providing a quick snapshot about celastrol giving a new direction in the area of herbal drug discovery and development.

引用

页码：1785 / 1792

页数：8

共 96 条

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