The Modulation of Pain by Metabotropic Glutamate Receptors 7 and 8 in the Dorsal Striatum

被引:21
|
作者
Boccella, Serena [1 ]
Marabese, Ida [1 ]
Guida, Francesca [1 ]
Luongo, Livio [1 ]
Maione, Sabatino [1 ]
Palazzo, Enza [1 ]
机构
[1] Univ Campania L Vanvitelli, Pharmacol Div, Dept Expt Med, Via Costantinopoli 16, I-80138 Naples, Italy
关键词
mGluR7; mGluR8; dorsal striatum; chronic pain; descending pain modulatory system; hyperglutamatergism; POSITIVE ALLOSTERIC MODULATOR; ROSTRAL VENTROMEDIAL MEDULLA; MESSENGER-RNA EXPRESSION; PRESYNAPTIC ACTIVE ZONES; CENTRAL-NERVOUS-SYSTEM; AMINO-ACID RELEASE; BASAL GANGLIA; PARKINSONS-DISEASE; MICE LACKING; MGLU8; RECEPTOR;
D O I
10.2174/1570159X17666190618121859
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The dorsal striatum, apart from controlling voluntary movement, displays a recently demonstrated pain inhibition. It is connected to the descending pain modulatory system and in particular to the rostral ventromedial medulla through the medullary dorsal reticular nucleus. Diseases of the basal ganglia, such as Parkinson's disease, in addition to being characterized by motor disorders, are associated with pain and hyperactivation of the excitatory transmission. A way to counteract glutamatergic hyperactivation is through the activation of group III metabotropic glutamate receptors (mGluRs), which are located on presynaptic terminals inhibiting neurotransmitter release. So far the mGluRs of group III have been the least investigated, owing to a lack of selective tools. More recently, selective ligands for each mGluR of group III, in particular positive and negative allosteric modulators, have been developed and the role of each subtype is starting to emerge. The neuroprotective potential of group III mGluRs in pathological conditions, such as those characterized by elevate glutamate, has been recently shown. In the dorsal striatum, mGluR7 and mGluR8 are located at glutamatergic corticostriatal terminals and their stimulation inhibits pain in pathological conditions such as neuropathic pain. The two receptors in the dorsal striatum have instead a different role in pain control in normal conditions. This review will discuss recent results focusing on the contribution of mGluR7 and mGluR8 in the dorsal striatal control of pain. The role of mGluR4, whose antiparkinsonian activity is widely reported, will also be addressed.
引用
收藏
页码:34 / 50
页数:17
相关论文
共 50 条
  • [41] Positive allosteric modulation of native metabotropic glutamate 1 receptors
    Kew, JNC
    Knoflach, F
    Mutel, V
    Jolidon, S
    Malherbe, P
    Vieira, E
    Wichmann, J
    Kemp, JA
    BRITISH JOURNAL OF PHARMACOLOGY, 2002, 135
  • [42] The metabotropic glutamate receptors
    Madge, DJ
    Batchelor, AM
    ANNUAL REPORTS IN MEDICINAL CHEMISTRY, VOL 31, 1996, 31 : 31 - 40
  • [43] Metabotropic glutamate receptors
    Pilc, A.
    Ossowska, K.
    AMINO ACIDS, 2007, 32 (02) : 165 - 167
  • [44] Peripheral metabotropic glutamate receptors: fight the pain where it hurts
    Neugebauer, V
    TRENDS IN NEUROSCIENCES, 2001, 24 (10) : 550 - 552
  • [45] Metabotropic glutamate receptors - important modulators of nociception and pain behavior
    Neugebauer, V
    PAIN, 2002, 98 (1-2) : 1 - 8
  • [46] Supraspinal metabotropic glutamate receptors: a target for pain relief and beyond
    Palazzo, Enza
    Marabese, Ida
    de Novellis, Vito
    Rossi, Francesco
    Maione, Sabatino
    EUROPEAN JOURNAL OF NEUROSCIENCE, 2014, 39 (03) : 444 - 454
  • [47] Selective activation of group I metabotropic glutamate receptors upregulates preprodynorphin, substance P, and preproenkephalin mRNA expression in rat dorsal striatum
    Mao, LM
    Wang, JQ
    SYNAPSE, 2001, 39 (01) : 82 - 94
  • [48] Dual modulation of excitatory synaptic transmission by agonists at group I metabotropic glutamate receptors in the rat spinal dorsal horn
    Zhong, J
    Gerber, G
    Kojic, L
    Randic, M
    BRAIN RESEARCH, 2000, 887 (02) : 359 - 377
  • [49] The Role of Group II Metabotropic Glutamate Receptors in the Striatum in Electroacupuncture Treatment of Parkinsonian Rats
    Jia, Yan-Jun
    Deng, Jia-Hui
    Zhang, Wen-Zhong
    Sun, Zuo-Li
    Yang, Jian
    Yu, Yan
    Gong, Xiao-Li
    Jia, Jun
    Wang, Xiao-Min
    CNS NEUROSCIENCE & THERAPEUTICS, 2017, 23 (01) : 23 - 32
  • [50] Functional involvement of group II metabotropic glutamate receptors in the ventral striatum of the rat.
    Amalric, M
    Breysse, N
    Risterrucci, C
    EUROPEAN JOURNAL OF NEUROSCIENCE, 2000, 12 : 507 - 507