Neuropsychological Predictors of Severe Functional Dependency in a Multiethnic Community Cohort of Individuals with Alzheimer's Disease

被引:2
作者
Carcamo, Jasmine [1 ]
Kociolek, Anton J. [1 ]
Fernandez, Kayri K. [1 ]
Gu, Yian [1 ,2 ,3 ,6 ]
Zhu, Carolyn W. [4 ,5 ]
Stern, Yaakov [1 ,2 ,3 ,7 ]
Cosentino, Stephanie [1 ,2 ,3 ]
机构
[1] Columbia Univ, Vagelos Coll Phys & Surg, Taub Inst Res Alzheimers Dis & Aging Brain, New York, NY 10032 USA
[2] Columbia Univ, Vagelos Coll Phys & Surg, Dept Neurol, New York, NY 10032 USA
[3] Columbia Univ, Vagelos Coll Phys & Surg, Gertrude H Sergievsky Ctr, New York, NY 10032 USA
[4] Icahn Sch Med Mt Sinai, Brookdale Dept Geriatr & Palliat Med, New York, NY 10029 USA
[5] James J Peters VA Med Ctr, Bronx, NY USA
[6] Columbia Univ, Dept Epidemiol, New York, NY 10032 USA
[7] Columbia Univ, Vagelos Coll Phys & Surg, Dept Psychiat, New York, NY 10032 USA
关键词
Alzheimer's disease; cognition; dementia; memory; neuropsychological tests; PATIENT DEPENDENCE; PROGRESSION;
D O I
10.3233/JAD-210019
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
To assess the predictive value of neuropsychological tests for severe dependency in Alzheimer's disease as defined by the Equivalent Institutional Care Rating Scale, in a multiethnic, community cohort. The sample included 146 elders from the Predictors 3 cohort. Cox proportional hazard models tested the predictive value of each neuropsychological test at baseline on relative risk of meeting severe dependency. Higher semantic processing and memory test scores at baseline were associated with lower risk of meeting severe dependency in the adjusted Cox models. The integrity of semantic processing and memory abilities in dementia appears to predict time to severe functional dependency.
引用
收藏
页码:539 / 544
页数:6
相关论文
共 13 条
[1]   Increased Reporting Accuracy of Alzheimer Disease Symptoms in Caribbean Hispanic Informants [J].
Azar, Martina ;
Zhu, Carolyn ;
DeFeis, Brittany ;
Gu, Yian ;
Ornstein, Katherine ;
Lawless, Siobhan ;
Cosentino, Stephanie .
ALZHEIMER DISEASE & ASSOCIATED DISORDERS, 2017, 31 (04) :328-334
[2]   Verbal fluency predicts mortality in Alzheimer disease [J].
Cosentino, Stephanie ;
Scarmeas, Nikolaos ;
Albert, Steven M. ;
Stern, Yaakov .
COGNITIVE AND BEHAVIORAL NEUROLOGY, 2006, 19 (03) :123-129
[3]   Progression of Mild Cognitive Impairment to Dementia in Clinic- vs Community-Based Cohorts [J].
Farias, Sarah Tomaszewski ;
Mungas, Dan ;
Reed, Bruce R. ;
Harvey, Danielle ;
DeCarli, Charles .
ARCHIVES OF NEUROLOGY, 2009, 66 (09) :1151-1157
[4]   Assessing Dependency in a Multiethnic Community Cohort of Individuals With Alzheimer's Disease [J].
Meinerding, Maria ;
DeFeis, Brittany ;
Sunderaraman, Preeti ;
Azar, Martina ;
Lawless, Siobhan ;
Perez-Vivaldo, Carlos ;
Gu, Yian ;
Stern, Yaakov ;
Cosentino, Stephanie .
INNOVATION IN AGING, 2018, 2 (01)
[5]   Neuropsychological predictors of dependency in patients with Alzheimer disease [J].
Sarazin, M ;
Stern, Y ;
Berr, C ;
Riba, A ;
Albert, M ;
Brandt, J ;
Dubois, B .
NEUROLOGY, 2005, 64 (06) :1027-1031
[6]   Do Neuropsychological Tests Have the Same Meaning in Spanish Speakers as They Do in English Speakers? [J].
Siedlecki, Karen L. ;
Manly, Jennifer J. ;
Brickman, Adam M. ;
Schupf, Nicole ;
Tang, Ming-Xin ;
Stern, Yaakov .
NEUROPSYCHOLOGY, 2010, 24 (03) :402-411
[7]   ASSESSING PATIENT DEPENDENCE IN ALZHEIMERS-DISEASE [J].
STERN, Y ;
ALBERT, SM ;
SANO, M ;
RICHARDS, M ;
MILLER, L ;
FOLSTEIN, M ;
ALBERT, M ;
BYLSMA, FW ;
LAFLECHE, G .
JOURNALS OF GERONTOLOGY, 1994, 49 (05) :M216-M222
[8]   UTILITY OF EXTRAPYRAMIDAL SIGNS AND PSYCHOSIS AS PREDICTORS OF COGNITIVE AND FUNCTIONAL DECLINE, NURSING-HOME ADMISSION, AND DEATH IN ALZHEIMERS-DISEASE - PROSPECTIVE ANALYSES FROM THE PREDICTORS STUDY [J].
STERN, Y ;
ALBERT, M ;
BRANDT, J ;
JACOBS, DM ;
TANG, MX ;
MARDER, K ;
BELL, K ;
SANO, M ;
DEVANAND, DP ;
BYLSMA, F ;
LAFLECHE, G .
NEUROLOGY, 1994, 44 (12) :2300-2307
[9]   The Predictors study: Development and baseline characteristics of the Predictors 3 cohort [J].
Stern, Yaakov ;
Gu, Yian ;
Cosentino, Stephanie ;
Azar, Martina ;
Lawless, Siobhan ;
Tatarina, Oksana .
ALZHEIMERS & DEMENTIA, 2017, 13 (01) :20-27
[10]   Semantic Memory in the Clinical Progression of Alzheimer Disease [J].
Tchakoute, Christophe T. ;
Sainani, Kristin L. ;
Henderson, Victor W. .
COGNITIVE AND BEHAVIORAL NEUROLOGY, 2017, 30 (03) :81-89