Trophoblast deportation and the maternal inflammatory response in pre-eclampsia

被引：181

作者：

Sargent, IL ^{[1
]}

Germain, SJ ^{[1
]}

Sacks, GP ^{[1
]}

Kumar, S ^{[1
]}

Redman, CWG ^{[1
]}

机构：

[1] John Radcliffe Hosp, Nuffield Dept Obstet & Gynaecol, Oxford OX3 9DU, England

来源：

JOURNAL OF REPRODUCTIVE IMMUNOLOGY | 2003年 / 59卷 / 02期

关键词：

pre-eclampsia; inflammatory response; trophoblast deportation;

D O I：

10.1016/S0165-0378(03)00044-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We have proposed that the maternal syndrome of pre-eclampsia is caused by a systemic inflammatory response involving both leucocytes and endothelium. This inflammatory response is present also in normal pregnancy, but in a milder form. The inflammatory stimulus is most likely to come from the placenta. Syncytiotrophoblast apoptotic debris, which is shed into the maternal circulation in normal pregnancy and in increased amounts in pre-eclampsia, may be the stimulus for this response. It may also contribute to the suppression of Th1 responses seen in pregnancy. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：153 / 160

页数：8

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