Copper-catalyzed amidation of Sp3 C-H bonds adjacent to a nitrogen atom

被引：138

作者：

Zhang, Yongming ^{[1
]}

Fu, Hua

Jiang, Yuyang

Zhao, Yufen

机构：

[1] Tsinghua Univ, Minist Educ, Dept Chem, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Beijing 100084, Peoples R China

[2] Tsing Hua Univ, Guangdong Prov Grad Sch Shenzhen, Key Lab Chem Biol, Shenzhen 518057, Peoples R China

来源：

ORGANIC LETTERS | 2007年 / 9卷 / 19期

关键词：

D O I：

10.1021/ol701715m

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We have developed a novel copper-catalyzed amidation of unactivated sp(3) C-H bonds adjacent to a nitrogen atom by using an inexpensive catalyst-oxidant (CuBr/(BuOOH)-Bu-t) system under mild conditions. The dephenylation was first found for N-benzylaniline, and the new class of products provide diverse structures for pharmaceuticals and combinatorial chemistry.

引用

页码：3813 / 3816

页数：4

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