All-cause mortality and estimated renal function in type 2 diabetes mellitus outpatients: Is there a relationship with the equation used?

被引：7

作者：

Fabbian, Fabio ^{[1
]}

De Giorgi, Alfredo ^{[1
]}

Monesi, Marcello ^{[2
]}

Pala, Marco ^{[1
]}

Tiseo, Ruana ^{[1
]}

Misurati, Elisa ^{[1
]}

Parisi, Claudia ^{[1
]}

Volpi, Riccardo ^{[3
]}

Graziani, Roberto ^{[2
]}

Mikhailidis, Dimitri P. ^{[4
]}

Manfredini, Roberto ^{[1
]}

机构：

[1] Univ Hosp St Anna, Operat Unit Clin Med, Dept Med Sci, I-44124 Ferrara, Italy

[2] Univ Hosp St Anna, I-44124 Ferrara, Italy

[3] Univ Parma, Dept Internal Med & Biomed Sci, I-43100 Parma, Italy

[4] UCL, Sch Med, Dept Clin Biochem, Vasc Dis Prevent Clin, London W1N 8AA, England

来源：

DIABETES & VASCULAR DISEASE RESEARCH | 2015年 / 12卷 / 01期

关键词：

Type 2 diabetes mellitus; glomerular filtration rate; equations; all-cause mortality; outpatients; kidney; GLOMERULAR-FILTRATION-RATE; CHRONIC KIDNEY-DISEASE; MYOCARDIAL-INFARCTION; SERUM CREATININE; RISK; ALBUMINURIA; DYSFUNCTION; EVENTS; DIET;

D O I：

10.1177/1479164114552656

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: We investigated the relationship between serum creatinine (SCr) and estimated glomerular filtration rate (eGFR), evaluated by different formulae, and all-cause mortality (ACM) in type 2 diabetes mellitus (T2DM) outpatients. Methods: This observational cohort study considered 1365 T2DM outpatients, who had been followed up for a period of up to 11years. eGFR was estimated using several equations. Results: Seventy subjects (5.1%) died after a follow-up of 9.8 3years. Univariate analysis showed that diagnosis of nephropathy (odds ratio (OR): 2.554, 95% confidence interval (CI): 1.616-4.038, p < 0.001) and microvascular complications (OR: 2.281, 95% CI: 1.449-3.593, p < 0.001) were associated with ACM. Receiving operating characteristic (ROC) curves showed that the areas under the curve for ACM were similar using the different eGFR equations. eGFR values were predictors of ACM, and the hazard ratios (HRs) of the different equations for eGFR estimation were similar. Conclusion: In our cohort of T2DM outpatients, different eGFR equations perform similarly in predicting ACM, whereas SCr did not.

引用

页码：46 / 52

页数：7

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