Analysis of regional MRI volumes and thicknesses as predictors of conversion from mild cognitive impairment to Alzheimer's disease

被引：97

作者：

Liu, Yawu ^{[1
]}

Paajanen, Teemu ^{[1
]}

Zhang, Yi ^{[2
]}

Westman, Eric ^{[2
]}

Wahlund, Lars-Olof ^{[2
]}

Simmons, Andrew ^{[3
,4
]}

Tunnard, Catherine ^{[3
]}

Sobow, Tomasz ^{[5
]}

Mecocci, Patrizia ^{[6
]}

Tsolaki, Magda ^{[7
]}

Vellas, Bruno ^{[8
]}

Muehlboeck, Sebastian ^{[9
]}

Evans, Alan ^{[9
]}

Spenger, Christian ^{[2
]}

Lovestone, Simon ^{[3
,4
]}

Soininen, Hilkka ^{[1
]}

机构：

[1] Univ Eastern Finland, Dept Neurol, Kuopio Univ Hosp, FIN-70211 Kuopio, Finland

[2] Karolinska Inst, Sect Clin Geriatr, Dept Neurobiol Care Sci & Soc, Stockholm, Sweden

[3] Kings Coll London, Inst Psychiat, MRC Ctr Neurodegenerat Res, London WC2R 2LS, England

[4] Maudsley NHS Fdn Trust, NIHR Biomed Res Ctr Mental Hlth S London, London, England

[5] Med Univ Lodz, Dept Old Age Psychiat & Psychot Disorders, Lodz, Poland

[6] Univ Perugia, Inst Gerontol & Geriatr, I-06100 Perugia, Italy

[7] Aristotle Univ Thessaloniki, Dept Neurol, GR-54006 Thessaloniki, Greece

[8] Univ Toulouse 3, INSERM, Toulouse Gerontopole Univ Hosp, F-31062 Toulouse, France

[9] McGill Univ, Frances McConnell Brain Imaging Ctr, Montreal, PQ, Canada

来源：

NEUROBIOLOGY OF AGING | 2010年 / 31卷 / 08期

基金：

芬兰科学院;

关键词：

Alzheimer's disease; Conversion; MCI; Mild cognitive impairment; MRI; VOXEL-BASED MORPHOMETRY; MAGNETIC-RESONANCE IMAGES; HUMAN CEREBRAL-CORTEX; GRAY-MATTER LOSS; ENTORHINAL CORTEX; HIPPOCAMPAL VOLUME; COORDINATE SYSTEM; CORTICAL SURFACE; HUMAN BRAIN; ATROPHY;

D O I：

10.1016/j.neurobiolaging.2010.01.022

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

We determined predictors of conversion to Alzheimer's disease (AD) from mild cognitive impairment (MCI) with automated magnetic resonance imaging (MRI) regional cortical volume and thickness measures. One hundred amnestic MCI subjects, 118 AD patients, and 94 age-matched healthy controls were selected from AddNeuroMed study. Twenty-four regional cortical volumes and 34 cortical thicknesses were measured with automated image processing software at baseline. Twenty-one subjects converted from MCI to AD determined with the cognitive tests at baseline and 1 year later. The hippocampus, amygdala, and caudate volumes were significantly smaller in progressive MCI subjects than in controls and stable MCI subjects. The cortical volumes achieved higher predictive accuracy than did cognitive tests or cortical thickness. Combining the volumes, thicknesses, and cognitive tests did not improve the accuracy. The volume of amygdala and caudate were independent variables in predicting conversion from MCI to AD. We conclude that regional cortical volume measures are more powerful than those common cognitive tests we used in identifying AD patients at the very earliest stage of the disease. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：1375 / 1385

页数：11

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