First tricyclic oximino derivatives as 5-HT3 ligands

被引：8
作者：
Baglin, I
Daveu, C
Lancelot, JC
Bureau, R
Dauphin, F
Pfeiffer, B
Renard, P
Delagrange, P
Rault, S
机构：
[1] Univ Caen, Ctr Etud & Rech Med Normandie, F-14032 Caen, France
[2] Univ Caen, Ctr Cyceron, CNRS, UMR 6551, F-14074 Caen, France
[3] ADIR & CIE, F-92415 Courbevoie, France
[4] Inst Rech Int Servier, F-92415 Courbevoie, France
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 04期
关键词：
D O I：
10.1016/S0960-894X(00)00691-0
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The design and synthesis of a new type of 5-HT3 ligand with subnanomolar affinity are described. The O-dialkyl-aminoethyloximinothienopyrrolizine structure was deduced from molecular modeling studies by replacement of an amidine moiety by an oximino one. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：453 / 457
页数：5
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