Pain is a hallmark feature of sickle cell anemia (SCA) but management of chronic as well as acute pain remains a major challenge. Mouse models of SCA are essential to examine the mechanisms of pain and develop novel therapeutics. To facilitate this effort, we compared humanized homozygous BERK and Townes sickle mice for the effect of gender and age on pain behaviors. Similar to previously characterized BERK sickle mice, Townes sickle mice show more mechanical, thermal, and deep tissue hyperalgesia with increasing age. Female Townes sickle mice demonstrate more hyperalgesia compared to males similar to that reported for BERK mice and patients with SCA. Mechanical, thermal and deep tissue hyperalgesia increased further after hypoxia/reoxygenation (H/R) treatment in Townes sickle mice. Together, these data show BERK sickle mice exhibit a significantly greater degree of hyperalgesia for all behavioral measures as compared to gender- and age-matched Townes sickle mice. However, the genetically distinct "knock-in" strategy of human alpha and beta transgene insertion in Townes mice as compared to BERK mice, may provide relative advantage for further genetic manipulations to examine specific mechanisms of pain.
机构:
Georgia Regents Univ, Dept Biochem & Mol Biol, Augusta, GA 30912 USAGeorgia Regents Univ, Dept Biochem & Mol Biol, Augusta, GA 30912 USA
Promsote, Wanwisa
Makala, Levi
论文数: 0引用数: 0
h-index: 0
机构:
Georgia Regents Univ, Dept Pediat, Augusta, GA 30912 USAGeorgia Regents Univ, Dept Biochem & Mol Biol, Augusta, GA 30912 USA
Makala, Levi
Li, Biaoru
论文数: 0引用数: 0
h-index: 0
机构:
Georgia Regents Univ, Dept Pediat, Augusta, GA 30912 USAGeorgia Regents Univ, Dept Biochem & Mol Biol, Augusta, GA 30912 USA
Li, Biaoru
Smith, Sylvia B.
论文数: 0引用数: 0
h-index: 0
机构:
Georgia Regents Univ, Dept Cellular Biol & Anat, Augusta, GA 30912 USA
Georgia Regents Univ, Dept Ophthalmol, Augusta, GA 30912 USA
Georgia Regents Univ, James & Jean Culver Vis Discovery Inst, Augusta, GA 30912 USAGeorgia Regents Univ, Dept Biochem & Mol Biol, Augusta, GA 30912 USA
Smith, Sylvia B.
Singh, Nagendra
论文数: 0引用数: 0
h-index: 0
机构:
Georgia Regents Univ, Dept Biochem & Mol Biol, Augusta, GA 30912 USA
Georgia Regents Univ, Ctr Canc, Augusta, GA 30912 USAGeorgia Regents Univ, Dept Biochem & Mol Biol, Augusta, GA 30912 USA
Singh, Nagendra
Ganapathy, Vadivel
论文数: 0引用数: 0
h-index: 0
机构:
Georgia Regents Univ, Dept Biochem & Mol Biol, Augusta, GA 30912 USA
Georgia Regents Univ, James & Jean Culver Vis Discovery Inst, Augusta, GA 30912 USA
Georgia Regents Univ, Ctr Canc, Augusta, GA 30912 USAGeorgia Regents Univ, Dept Biochem & Mol Biol, Augusta, GA 30912 USA
Ganapathy, Vadivel
Pace, Betty S.
论文数: 0引用数: 0
h-index: 0
机构:
Georgia Regents Univ, Dept Pediat, Augusta, GA 30912 USA
Georgia Regents Univ, Ctr Canc, Augusta, GA 30912 USAGeorgia Regents Univ, Dept Biochem & Mol Biol, Augusta, GA 30912 USA
Pace, Betty S.
Martin, Pamela M.
论文数: 0引用数: 0
h-index: 0
机构:
Georgia Regents Univ, Dept Biochem & Mol Biol, Augusta, GA 30912 USA
Georgia Regents Univ, Dept Ophthalmol, Augusta, GA 30912 USA
Georgia Regents Univ, James & Jean Culver Vis Discovery Inst, Augusta, GA 30912 USA
Georgia Regents Univ, Ctr Canc, Augusta, GA 30912 USAGeorgia Regents Univ, Dept Biochem & Mol Biol, Augusta, GA 30912 USA
机构:
Virginia Commonwealth Univ, Dept Internal Med, Div Quality Hlth Care, Richmond, VA 23298 USAVirginia Commonwealth Univ, Dept Internal Med, Div Quality Hlth Care, Richmond, VA 23298 USA
Smith, Wally R.
Penberthy, Lynne T.
论文数: 0引用数: 0
h-index: 0
机构:
Virginia Commonwealth Univ, Dept Internal Med, Div Quality Hlth Care, Richmond, VA 23298 USAVirginia Commonwealth Univ, Dept Internal Med, Div Quality Hlth Care, Richmond, VA 23298 USA
Penberthy, Lynne T.
Bovbjerg, Viktor E.
论文数: 0引用数: 0
h-index: 0
机构:
Virginia Commonwealth Univ, Dept Internal Med, Div Quality Hlth Care, Richmond, VA 23298 USAVirginia Commonwealth Univ, Dept Internal Med, Div Quality Hlth Care, Richmond, VA 23298 USA
Bovbjerg, Viktor E.
McClish, Donna K.
论文数: 0引用数: 0
h-index: 0
机构:
Virginia Commonwealth Univ, Dept Internal Med, Div Quality Hlth Care, Richmond, VA 23298 USAVirginia Commonwealth Univ, Dept Internal Med, Div Quality Hlth Care, Richmond, VA 23298 USA
McClish, Donna K.
Roberts, John D.
论文数: 0引用数: 0
h-index: 0
机构:
Virginia Commonwealth Univ, Dept Internal Med, Div Quality Hlth Care, Richmond, VA 23298 USAVirginia Commonwealth Univ, Dept Internal Med, Div Quality Hlth Care, Richmond, VA 23298 USA
Roberts, John D.
Dahman, Bassarn
论文数: 0引用数: 0
h-index: 0
机构:
Virginia Commonwealth Univ, Dept Internal Med, Div Quality Hlth Care, Richmond, VA 23298 USAVirginia Commonwealth Univ, Dept Internal Med, Div Quality Hlth Care, Richmond, VA 23298 USA
Dahman, Bassarn
Aisiku, Imoigele P.
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h-index: 0
机构:
Virginia Commonwealth Univ, Dept Internal Med, Div Quality Hlth Care, Richmond, VA 23298 USAVirginia Commonwealth Univ, Dept Internal Med, Div Quality Hlth Care, Richmond, VA 23298 USA
Aisiku, Imoigele P.
Levenson, James L.
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h-index: 0
机构:
Virginia Commonwealth Univ, Dept Internal Med, Div Quality Hlth Care, Richmond, VA 23298 USAVirginia Commonwealth Univ, Dept Internal Med, Div Quality Hlth Care, Richmond, VA 23298 USA
Levenson, James L.
Roseff, Susan D.
论文数: 0引用数: 0
h-index: 0
机构:
Virginia Commonwealth Univ, Dept Internal Med, Div Quality Hlth Care, Richmond, VA 23298 USAVirginia Commonwealth Univ, Dept Internal Med, Div Quality Hlth Care, Richmond, VA 23298 USA
机构:
Virginia Commonwealth Univ, Internal Med Div Qual Hlth Care, Richmond, VA 23298 USAVirginia Commonwealth Univ, Internal Med Div Qual Hlth Care, Richmond, VA 23298 USA
Smith, Wally R.
Bauserman, Robert L.
论文数: 0引用数: 0
h-index: 0
机构:
Virginia Commonwealth Univ, Internal Med Div Qual Hlth Care, Richmond, VA 23298 USAVirginia Commonwealth Univ, Internal Med Div Qual Hlth Care, Richmond, VA 23298 USA
Bauserman, Robert L.
Ballas, Samir K.
论文数: 0引用数: 0
h-index: 0
机构:
Virginia Commonwealth Univ, Internal Med Div Qual Hlth Care, Richmond, VA 23298 USAVirginia Commonwealth Univ, Internal Med Div Qual Hlth Care, Richmond, VA 23298 USA
Ballas, Samir K.
McCarthy, William F.
论文数: 0引用数: 0
h-index: 0
机构:
Virginia Commonwealth Univ, Internal Med Div Qual Hlth Care, Richmond, VA 23298 USAVirginia Commonwealth Univ, Internal Med Div Qual Hlth Care, Richmond, VA 23298 USA
McCarthy, William F.
Steinberg, Martin H.
论文数: 0引用数: 0
h-index: 0
机构:
Virginia Commonwealth Univ, Internal Med Div Qual Hlth Care, Richmond, VA 23298 USAVirginia Commonwealth Univ, Internal Med Div Qual Hlth Care, Richmond, VA 23298 USA
Steinberg, Martin H.
Swerdlow, Paul S.
论文数: 0引用数: 0
h-index: 0
机构:
Virginia Commonwealth Univ, Internal Med Div Qual Hlth Care, Richmond, VA 23298 USAVirginia Commonwealth Univ, Internal Med Div Qual Hlth Care, Richmond, VA 23298 USA
Swerdlow, Paul S.
Waclawiw, Myron A.
论文数: 0引用数: 0
h-index: 0
机构:
Virginia Commonwealth Univ, Internal Med Div Qual Hlth Care, Richmond, VA 23298 USAVirginia Commonwealth Univ, Internal Med Div Qual Hlth Care, Richmond, VA 23298 USA
Waclawiw, Myron A.
Barton, Bruce A.
论文数: 0引用数: 0
h-index: 0
机构:
Virginia Commonwealth Univ, Internal Med Div Qual Hlth Care, Richmond, VA 23298 USAVirginia Commonwealth Univ, Internal Med Div Qual Hlth Care, Richmond, VA 23298 USA
机构:
Georgia Regents Univ, Dept Biochem & Mol Biol, Augusta, GA 30912 USAGeorgia Regents Univ, Dept Biochem & Mol Biol, Augusta, GA 30912 USA
Promsote, Wanwisa
Makala, Levi
论文数: 0引用数: 0
h-index: 0
机构:
Georgia Regents Univ, Dept Pediat, Augusta, GA 30912 USAGeorgia Regents Univ, Dept Biochem & Mol Biol, Augusta, GA 30912 USA
Makala, Levi
Li, Biaoru
论文数: 0引用数: 0
h-index: 0
机构:
Georgia Regents Univ, Dept Pediat, Augusta, GA 30912 USAGeorgia Regents Univ, Dept Biochem & Mol Biol, Augusta, GA 30912 USA
Li, Biaoru
Smith, Sylvia B.
论文数: 0引用数: 0
h-index: 0
机构:
Georgia Regents Univ, Dept Cellular Biol & Anat, Augusta, GA 30912 USA
Georgia Regents Univ, Dept Ophthalmol, Augusta, GA 30912 USA
Georgia Regents Univ, James & Jean Culver Vis Discovery Inst, Augusta, GA 30912 USAGeorgia Regents Univ, Dept Biochem & Mol Biol, Augusta, GA 30912 USA
Smith, Sylvia B.
Singh, Nagendra
论文数: 0引用数: 0
h-index: 0
机构:
Georgia Regents Univ, Dept Biochem & Mol Biol, Augusta, GA 30912 USA
Georgia Regents Univ, Ctr Canc, Augusta, GA 30912 USAGeorgia Regents Univ, Dept Biochem & Mol Biol, Augusta, GA 30912 USA
Singh, Nagendra
Ganapathy, Vadivel
论文数: 0引用数: 0
h-index: 0
机构:
Georgia Regents Univ, Dept Biochem & Mol Biol, Augusta, GA 30912 USA
Georgia Regents Univ, James & Jean Culver Vis Discovery Inst, Augusta, GA 30912 USA
Georgia Regents Univ, Ctr Canc, Augusta, GA 30912 USAGeorgia Regents Univ, Dept Biochem & Mol Biol, Augusta, GA 30912 USA
Ganapathy, Vadivel
Pace, Betty S.
论文数: 0引用数: 0
h-index: 0
机构:
Georgia Regents Univ, Dept Pediat, Augusta, GA 30912 USA
Georgia Regents Univ, Ctr Canc, Augusta, GA 30912 USAGeorgia Regents Univ, Dept Biochem & Mol Biol, Augusta, GA 30912 USA
Pace, Betty S.
Martin, Pamela M.
论文数: 0引用数: 0
h-index: 0
机构:
Georgia Regents Univ, Dept Biochem & Mol Biol, Augusta, GA 30912 USA
Georgia Regents Univ, Dept Ophthalmol, Augusta, GA 30912 USA
Georgia Regents Univ, James & Jean Culver Vis Discovery Inst, Augusta, GA 30912 USA
Georgia Regents Univ, Ctr Canc, Augusta, GA 30912 USAGeorgia Regents Univ, Dept Biochem & Mol Biol, Augusta, GA 30912 USA
机构:
Virginia Commonwealth Univ, Dept Internal Med, Div Quality Hlth Care, Richmond, VA 23298 USAVirginia Commonwealth Univ, Dept Internal Med, Div Quality Hlth Care, Richmond, VA 23298 USA
Smith, Wally R.
Penberthy, Lynne T.
论文数: 0引用数: 0
h-index: 0
机构:
Virginia Commonwealth Univ, Dept Internal Med, Div Quality Hlth Care, Richmond, VA 23298 USAVirginia Commonwealth Univ, Dept Internal Med, Div Quality Hlth Care, Richmond, VA 23298 USA
Penberthy, Lynne T.
Bovbjerg, Viktor E.
论文数: 0引用数: 0
h-index: 0
机构:
Virginia Commonwealth Univ, Dept Internal Med, Div Quality Hlth Care, Richmond, VA 23298 USAVirginia Commonwealth Univ, Dept Internal Med, Div Quality Hlth Care, Richmond, VA 23298 USA
Bovbjerg, Viktor E.
McClish, Donna K.
论文数: 0引用数: 0
h-index: 0
机构:
Virginia Commonwealth Univ, Dept Internal Med, Div Quality Hlth Care, Richmond, VA 23298 USAVirginia Commonwealth Univ, Dept Internal Med, Div Quality Hlth Care, Richmond, VA 23298 USA
McClish, Donna K.
Roberts, John D.
论文数: 0引用数: 0
h-index: 0
机构:
Virginia Commonwealth Univ, Dept Internal Med, Div Quality Hlth Care, Richmond, VA 23298 USAVirginia Commonwealth Univ, Dept Internal Med, Div Quality Hlth Care, Richmond, VA 23298 USA
Roberts, John D.
Dahman, Bassarn
论文数: 0引用数: 0
h-index: 0
机构:
Virginia Commonwealth Univ, Dept Internal Med, Div Quality Hlth Care, Richmond, VA 23298 USAVirginia Commonwealth Univ, Dept Internal Med, Div Quality Hlth Care, Richmond, VA 23298 USA
Dahman, Bassarn
Aisiku, Imoigele P.
论文数: 0引用数: 0
h-index: 0
机构:
Virginia Commonwealth Univ, Dept Internal Med, Div Quality Hlth Care, Richmond, VA 23298 USAVirginia Commonwealth Univ, Dept Internal Med, Div Quality Hlth Care, Richmond, VA 23298 USA
Aisiku, Imoigele P.
Levenson, James L.
论文数: 0引用数: 0
h-index: 0
机构:
Virginia Commonwealth Univ, Dept Internal Med, Div Quality Hlth Care, Richmond, VA 23298 USAVirginia Commonwealth Univ, Dept Internal Med, Div Quality Hlth Care, Richmond, VA 23298 USA
Levenson, James L.
Roseff, Susan D.
论文数: 0引用数: 0
h-index: 0
机构:
Virginia Commonwealth Univ, Dept Internal Med, Div Quality Hlth Care, Richmond, VA 23298 USAVirginia Commonwealth Univ, Dept Internal Med, Div Quality Hlth Care, Richmond, VA 23298 USA
机构:
Virginia Commonwealth Univ, Internal Med Div Qual Hlth Care, Richmond, VA 23298 USAVirginia Commonwealth Univ, Internal Med Div Qual Hlth Care, Richmond, VA 23298 USA
Smith, Wally R.
Bauserman, Robert L.
论文数: 0引用数: 0
h-index: 0
机构:
Virginia Commonwealth Univ, Internal Med Div Qual Hlth Care, Richmond, VA 23298 USAVirginia Commonwealth Univ, Internal Med Div Qual Hlth Care, Richmond, VA 23298 USA
Bauserman, Robert L.
Ballas, Samir K.
论文数: 0引用数: 0
h-index: 0
机构:
Virginia Commonwealth Univ, Internal Med Div Qual Hlth Care, Richmond, VA 23298 USAVirginia Commonwealth Univ, Internal Med Div Qual Hlth Care, Richmond, VA 23298 USA
Ballas, Samir K.
McCarthy, William F.
论文数: 0引用数: 0
h-index: 0
机构:
Virginia Commonwealth Univ, Internal Med Div Qual Hlth Care, Richmond, VA 23298 USAVirginia Commonwealth Univ, Internal Med Div Qual Hlth Care, Richmond, VA 23298 USA
McCarthy, William F.
Steinberg, Martin H.
论文数: 0引用数: 0
h-index: 0
机构:
Virginia Commonwealth Univ, Internal Med Div Qual Hlth Care, Richmond, VA 23298 USAVirginia Commonwealth Univ, Internal Med Div Qual Hlth Care, Richmond, VA 23298 USA
Steinberg, Martin H.
Swerdlow, Paul S.
论文数: 0引用数: 0
h-index: 0
机构:
Virginia Commonwealth Univ, Internal Med Div Qual Hlth Care, Richmond, VA 23298 USAVirginia Commonwealth Univ, Internal Med Div Qual Hlth Care, Richmond, VA 23298 USA
Swerdlow, Paul S.
Waclawiw, Myron A.
论文数: 0引用数: 0
h-index: 0
机构:
Virginia Commonwealth Univ, Internal Med Div Qual Hlth Care, Richmond, VA 23298 USAVirginia Commonwealth Univ, Internal Med Div Qual Hlth Care, Richmond, VA 23298 USA
Waclawiw, Myron A.
Barton, Bruce A.
论文数: 0引用数: 0
h-index: 0
机构:
Virginia Commonwealth Univ, Internal Med Div Qual Hlth Care, Richmond, VA 23298 USAVirginia Commonwealth Univ, Internal Med Div Qual Hlth Care, Richmond, VA 23298 USA