Primary sclerosing cholangitis is a premalignant condition

被引：1

作者：

Schramm, C

Galle, RR

机构：

[1] Johannes Gutenberg Univ Mainz, Med Klin & Poliklin, D-55101 Mainz, Germany

[2] Univ Klinikum Hamburg, Med Klin 1, Hamburg, Germany

来源：

ZEITSCHRIFT FUR GASTROENTEROLOGIE | 2005年 / 43卷 / 06期

关键词：

primary sclerosing cholangitis; cholangiocarcinoma; prevalence; tumor markers; CEA; CA19-9; brush cytology; liver transplantation; ursodeoxycholic acid; UDCA;

D O I：

10.1055/s-2005-858311

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Primary sclerosing cholangitis is a chronic cholestatic liver disease of unknown aetiology. The course of the disease is usually progressive with the development of liver cirrhosis leading to death or liver transplantation within an average of 12 years. To date it is well known that the development of hepatobiliary malignancies and the rate of colonic mucosal dysplasia and carcinoma in patients with concomitant ulcerative colitis are greatly enhanced in patients with PSC. PSC can therefore be regarded as a premalignant condition. The following review will focus on the development of cholangiocellular carcinoma in patients with PSC and the associated diagnostic and therapeutic challenges.

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页码：607 / 611

页数：5

相关论文

共 51 条

[1] Chromosome 9p21 loss and p16 inactivation in primary sclerosing cholangitis-associated cholangiocarcinoma [J].

Ahrendt, SA ;

Eisenberger, CF ;

Yip, L ;

Rashid, A ;

Chow, JT ;

Pitt, HA ;

Sidransky, D .

JOURNAL OF SURGICAL RESEARCH, 1999, 84 (01) :88-93

[2] Diagnosis and management of cholangiocarcinoma in primary sclerosing cholangitis [J].

Ahrendt, SA ;

Pitt, HA ;

Nakeeb, A ;

Klein, AS ;

Lillemoe, KD ;

Kalloo, AN ;

Cameron, JL .

JOURNAL OF GASTROINTESTINAL SURGERY, 1999, 3 (04) :357-367

[3] Magnetic resonance cholangiography in patients with biliary disease: its role in primary sclerosing cholangitis [J].

Angulo, P ;

Pearce, DH ;

Johnson, CD ;

Henry, JJ ;

LaRusso, NF ;

Petersen, BT ;

Lindor, KD .

JOURNAL OF HEPATOLOGY, 2000, 33 (04) :520-527

[4] Primary sclerosing cholangitis [J].

Angulo, P ;

Lindor, KD .

HEPATOLOGY, 1999, 30 (01) :325-332

[5] Time course of histological progression in primary sclerosing cholangitis [J].

Angulo, P ;

Larson, DR ;

Therneau, TM ;

LaRusso, NF ;

Batts, KP ;

Lindor, KD .

AMERICAN JOURNAL OF GASTROENTEROLOGY, 1999, 94 (11) :3310-3313

[6] Incidence, clinical spectrum, and outcomes of primary sclerosing cholangitis in a United States community [J].

Bambha, K ;

Kim, WR ;

Talwalkar, J ;

Torgerson, H ;

Benson, JT ;

Therneau, TM ;

Loftus, EV ;

Yawn, BP ;

Dickson, ER ;

Melton, LJ .

GASTROENTEROLOGY, 2003, 125 (05) :1364-1369

[7] Risk factors and clinical presentation of hepatobiliary carcinoma in patients with primary sclerosing cholangitis:: A case-control study [J].

Bergquist, A ;

Glaumann, H ;

Persson, B ;

Broomé, U .

HEPATOLOGY, 1998, 27 (02) :311-316

[8] Hepatic and extrahepatic malignancies in primary sclerosing cholangitis [J].

Bergquist, A ;

Ekbom, A ;

Olsson, R ;

Kornfeldt, D ;

Lööf, L ;

Danielsson, Å ;

Hultcrantz, R ;

Lindgren, S ;

Prytz, H ;

Sandberg-Gertzén, H ;

Almer, S ;

Granath, F ;

Broomé, U .

JOURNAL OF HEPATOLOGY, 2002, 36 (03) :321-327

[9] Patients with small duct primary sclerosing cholangitis have a favourable long term prognosis [J].

Björnsson, E ;

Boberg, KM ;

Cullen, S ;

Fleming, K ;

Clausen, OP ;

Fausa, O ;

Schrumpf, E ;

Chapman, RW .

GUT, 2002, 51 (05) :731-735

[10] Cholangiocarcinoma in primary sclerosing cholangitis:: K-ras mutations and Tp53 dysfunction are implicated in the neoplastic development [J].

Boberg, KM ;

Schrumpf, E ;

Bergquist, A ;

Broomé, U ;

Pares, A ;

Remotti, H ;

Schjölberg, A ;

Spurkland, A ;

Clausen, OPF .

JOURNAL OF HEPATOLOGY, 2000, 32 (03) :374-380

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