23, 22 Calling the Microbiota to Control Atherosclerosis

被引：4

作者：

Carreras, Alba ^{[1
,2
]}

Backhed, Fredrik ^{[1
,2
,3
]}

机构：

[1] Univ Gothenburg, Inst Med, Wallenberg Lab, Dept Mol & Clin Med, Gothenburg, Sweden

[2] Sahlgrens Univ Hosp, Gothenburg, Sweden

[3] Univ Copenhagen, Sect Metab Receptol & Enteroendocrinol, Novo Nordisk Fdn Ctr Basic Metab Res, Fac Hlth Sci, Copenhagen, Denmark

来源：

IMMUNITY | 2018年 / 49卷 / 05期

基金：

欧洲研究理事会;

关键词：

D O I：

10.1016/j.immuni.2018.11.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

While the commensal microbiota is considered an important regulator of immunity and metabolism, the mechanisms controlling the interplay between diet, cytokine signaling, and the microbiota in atherosclerosis remains unknown. In this issue of Immunity, Fatkhullina et al. (2018) demonstrate that interlukin-23-22 axis regulates diet-induced atherosclerosis by repressing pro-atherogenic microbiota.

引用

页码：788 / 790

页数：4

共 10 条

[1] Diet rapidly and reproducibly alters the human gut microbiome [J].

David, Lawrence A. ;

Maurice, Corinne F. ;

Carmody, Rachel N. ;

Gootenberg, David B. ;

Button, Julie E. ;

Wolfe, Benjamin E. ;

Ling, Alisha V. ;

Devlin, A. Sloan ;

Varma, Yug ;

Fischbach, Michael A. ;

Biddinger, Sudha B. ;

Dutton, Rachel J. ;

Turnbaugh, Peter J. .

NATURE, 2014, 505 (7484) :559-+

[2] An Interleukin-23-Interleukin-22 Axis Regulates Intestinal Microbial Homeostasis to Protect from Diet-Induced Atherosclerosis [J].

Fatkhullina, Aliia R. ;

Peshkova, Iuliia O. ;

Dzutsev, Amiran ;

Aghayev, Turan ;

McCulloch, John A. ;

Thovarai, Vishal ;

Badger, Jonathan H. ;

Vats, Ravi ;

Sundd, Prithu ;

Tang, Hsin-Yao ;

Kossenkov, Andrew V. ;

Hazen, Stanley L. ;

Trinchieri, Giorgio ;

Grivennikov, Sergei I. ;

Koltsova, Ekaterina K. .

IMMUNITY, 2018, 49 (05) :943-+

[3] Impact of Gut Microbiota and Diet on the Development of Atherosclerosis in Apoe-/- Mice [J].

Jonsson, Annika Lindskog ;

Caesar, Robert ;

Akrami, Rozita ;

Reinhardt, Christoph ;

Hallenius, Frida Fak ;

Boren, Jan ;

Baeckhed, Fredrik .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2018, 38 (10) :2318-2326

[4] Role of gut microbiota in atherosclerosis [J].

Jonsson, Annika Lindskog ;

Backhed, Fredrik .

NATURE REVIEWS CARDIOLOGY, 2017, 14 (02) :79-87

[5] Osteopontin deficiency attenuates atherosclerosis in female apolipoprotein E-deficient mice [J].

Matsui, Y ;

Rittling, SR ;

Okamoto, H ;

Inobe, M ;

Jia, N ;

Shimizu, T ;

Akino, M ;

Sugawara, T ;

Morimoto, J ;

Kimura, C ;

Kon, S ;

Denhardt, D ;

Kitabatake, A ;

Uede, T .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2003, 23 (06) :1029-1034

[6] Circulating trimethylamine N-oxide and the risk of cardiovascular diseases: a systematic review and meta-analysis of 11 prospective cohort studies [J].

Qi, Jiaqian ;

You, Tao ;

Li, Jing ;

Pan, Tingting ;

Xiang, Li ;

Han, Yue ;

Zhu, Li .

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2018, 22 (01) :185-194

[7] Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease [J].

Wang, Zeneng ;

Klipfell, Elizabeth ;

Bennett, Brian J. ;

Koeth, Robert ;

Levison, Bruce S. ;

Dugar, Brandon ;

Feldstein, Ariel E. ;

Britt, Earl B. ;

Fu, Xiaoming ;

Chung, Yoon-Mi ;

Wu, Yuping ;

Schauer, Phil ;

Smith, Jonathan D. ;

Allayee, Hooman ;

Tang, W. H. Wilson ;

DiDonato, Joseph A. ;

Lusis, Aldons J. ;

Hazen, Stanley L. .

NATURE, 2011, 472 (7341) :57-U82

[8] Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature death [J].

Wiekowski, MT ;

Leach, MW ;

Evans, EW ;

Sullivan, L ;

Chen, SC ;

Vassileva, G ;

Bazan, JF ;

Gorman, DM ;

Kastelein, RA ;

Narula, S ;

Lira, SA .

JOURNAL OF IMMUNOLOGY, 2001, 166 (12) :7563-7570

[9] IL-22 Deficiency Alters Colonic Microbiota To Be Transmissible and Colitogenic [J].

Zenewicz, Lauren A. ;

Yin, Xiaochen ;

Wang, Guoyang ;

Elinav, Eran ;

Hao, Liming ;

Zhao, Liping ;

Flavell, Richard A. .

JOURNAL OF IMMUNOLOGY, 2013, 190 (10) :5306-5312

[10] Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens [J].

Zheng, Yan ;

Valdez, Patricia A. ;

Danilenko, Dimitry M. ;

Hu, Yan ;

Sa, Susan M. ;

Gong, Qian ;

Abbas, Alexander R. ;

Modrusan, Zora ;

Ghilardi, Nico ;

de Sauvage, Frederic J. ;

Ouyang, Wenjun .

NATURE MEDICINE, 2008, 14 (03) :282-289

← 1 →