A review of remdesivir for COVID-19 in pregnancy and lactation

被引：22

作者：

Jorgensen, Sarah C. J. ^{[1
]}

Davis, Matthew R. ^{[2
]}

Lapinsky, Stephen E. ^{[3
,4
]}

机构：

[1] Mt Sinai Hosp, Dept Pharm, Toronto, ON, Canada

[2] Univ Calif Los Angeles, Ronald Reagan Med Ctr, Dept Pharm, Los Angeles, CA USA

[3] Mt Sinai Hosp, Div Respirol, Toronto, ON, Canada

[4] Univ Toronto, Interdept Div Crit Care Med, Toronto, ON, Canada

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 2022年 / 77卷 / 01期

关键词：

WOMEN; OUTCOMES;

D O I：

10.1093/jac/dkab311

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Mounting evidence suggests that pregnant people have an elevated risk of severe COVID-19-related complications compared with their non-pregnant counterparts, underscoring the need for effective prevention and treatment strategies. However, despite progress in innovative and flexible trial designs during the COVID-19 pandemic, regressive policies excluding pregnant and breastfeeding people from biomedical research persist. Remdesivir, a broad-spectrum antiviral, was the first drug licensed for the treatment of COVID-19, based on data showing it reduced the time to recovery in hospitalized patients. Pregnant and breastfeeding people were specifically excluded from all clinical trials of remdesivir in COVID-19, but data are accumulating from post-marketing registries, compassionate use programmes and case series/reports. In this review we synthesize these data and highlight key knowledge gaps to help inform clinical decision-making about its use in pregnancy and lactation.

引用

页码：24 / 30

页数：7

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