Fully automated whole-body registration in mice using an articulated skeleton atlas
被引:16
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Baiker, M.
[1
,2
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Milles, J.
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Leiden Univ, Med Ctr, Dept Radiol, Div Image Proc, NL-2300 RA Leiden, NetherlandsLeiden Univ, Med Ctr, Dept Radiol, Div Image Proc, NL-2300 RA Leiden, Netherlands
Milles, J.
[1
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Vossepoell, A. M.
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Delft Univ Technol, Quantitative Imag Grp, Delft, NetherlandsLeiden Univ, Med Ctr, Dept Radiol, Div Image Proc, NL-2300 RA Leiden, Netherlands
Vossepoell, A. M.
[2
]
Que, I.
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机构:Leiden Univ, Med Ctr, Dept Radiol, Div Image Proc, NL-2300 RA Leiden, Netherlands
Que, I.
Kaijzel, E. L.
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Leiden Univ Med, Dept Endocrinol, Leiden, NetherlandsLeiden Univ, Med Ctr, Dept Radiol, Div Image Proc, NL-2300 RA Leiden, Netherlands
Kaijzel, E. L.
[3
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Lowik, C. W. G. M.
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Leiden Univ Med, Dept Endocrinol, Leiden, NetherlandsLeiden Univ, Med Ctr, Dept Radiol, Div Image Proc, NL-2300 RA Leiden, Netherlands
Lowik, C. W. G. M.
[3
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Reiber, J. H. C.
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Leiden Univ, Med Ctr, Dept Radiol, Div Image Proc, NL-2300 RA Leiden, NetherlandsLeiden Univ, Med Ctr, Dept Radiol, Div Image Proc, NL-2300 RA Leiden, Netherlands
Reiber, J. H. C.
[1
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Dykstra, J.
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Leiden Univ, Med Ctr, Dept Radiol, Div Image Proc, NL-2300 RA Leiden, NetherlandsLeiden Univ, Med Ctr, Dept Radiol, Div Image Proc, NL-2300 RA Leiden, Netherlands
Dykstra, J.
[1
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Lelieveldt, B. P. F.
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Leiden Univ, Med Ctr, Dept Radiol, Div Image Proc, NL-2300 RA Leiden, NetherlandsLeiden Univ, Med Ctr, Dept Radiol, Div Image Proc, NL-2300 RA Leiden, Netherlands
Lelieveldt, B. P. F.
[1
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机构:
[1] Leiden Univ, Med Ctr, Dept Radiol, Div Image Proc, NL-2300 RA Leiden, Netherlands
In this paper, we propose a fully automated articulated registration approach for whole-body 3D data of mice. The method is based on a hierarchical anatomical model of the skeletal system where we specified position and degrees of freedom for each joint. Model fitting is performed by traversing a hierarchical part-tree, which enables a coarse-to-fine registration from the inner articulations outwards. The method was tested on 12 Micro-CT volumes, giving accurate alignment of the skeletal structures in all cases.