Dual drugs release from nanoporously bioactive coating on polyetheretherketone for enhancement of antibacterial activity, rBMSCs responses and osseointegration

被引：16

作者：

Zou, Fei ^{[1
]}

Lv, Feizhou ^{[1
]}

Ma, Xiaosheng ^{[1
]}

Xia, Xinlei ^{[1
]}

Cai, Liang ^{[3
]}

Mei, Shiqi ^{[3
]}

Wei, Jie ^{[3
]}

Niu, Yunfei ^{[2
]}

Jiang, Jianyuan ^{[1
]}

机构：

[1] Fudan Univ, Huashan Hosp, Dept Orthopaed, Shanghai 200040, Peoples R China

[2] Second Mil Med Univ, Changhai Hosp, Dept Orthopaed, Shanghai 200433, Peoples R China

[3] East China Univ Sci & Technol, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China

来源：

MATERIALS & DESIGN | 2020年 / 188卷

基金：

中国国家自然科学基金;

关键词：

Polyetheretherketone; Nanoporous coating; Dual drugs; Antibacterial activity; Osseointegration; IN-VITRO; SULFONATED POLYETHERETHERKETONE; SUSTAINED-RELEASE; BONE; TITANIUM; SURFACE; PEEK; OSTEOGENESIS; INTERFACE; GENISTEIN;

D O I：

10.1016/j.matdes.2019.108433

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

A bioactive coating of nanoporous magnesium calcium silicate (n-MCS) on polyetheretherketone (ncPK) surface was prepared, and dual drugs of genistein (GS) and curcumin (CR) were co-loaded into coating of ncPK (dncPK). The results revealed that compared with polyetheretherketone (PEEK), surface roughness, wettability and apatite mineralization ability of both ncPK and dncPK obviously improved, which promoted the rat bone mesenchymal stem cells (rBMSCs) adhesion. In addition, compared with ncPK and PEEK, dncPK significantly promoted the proliferation and differentiation of rBMSCs. Compared with ncPK and PEEK, dncPK displayed superior antibacterial activity to Escherichia coli and Staphylococcus aureus. The Micro-CT, histological and push-out load evaluations revealed that compared with ncPK and PEEK, dncPK remarkably accelerated osteogenesis and osseointegration in vivo. The results demonstrated that dual drugs-loaded dncPK exhibited good antibacterial activity and osteogenic activity, and significantly enhanced osteogenesis and osseointegration, which could be an alternative candidate as an implant in orthopedic and dental applications. (C) 2019 The Authors. Published by Elsevier Ltd.

引用

页数：14

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