6-Gingerol inhibits hair cycle via induction of MMP2 and MMP9 expression

被引:10
作者
Hou, Chun [1 ]
Miao, Yong [2 ]
Ji, Hang [1 ]
Wang, Susheng [1 ]
Liang, Gang [1 ]
Zhang, Zhihua [1 ]
Hong, Weijin [2 ]
机构
[1] Guangzhou Med Univ, Dept Plast & Cosmet Surg, Affiliated Hosp 1, Guangzhou 510120, Guangdong, Peoples R China
[2] Southern Med Univ, Nanfang Hosp, Dept Plast & Cosmet Surg, Guangzhou 510120, Guangdong, Peoples R China
来源
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS | 2017年 / 89卷 / 04期
关键词
MMP2; MMP9; 6-Gingerol; hair growth; FACTOR SCATTER FACTOR; OUTER ROOT SHEATH; DERMAL PAPILLA; GROWTH-FACTOR; CONDITIONED MEDIUM; FOLLICLE; GINGER; INSULIN; CELLS; STRESS;
D O I
10.1590/0001-3765201720170354
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
6-Gingerol is the major active constituent of ginger. In the current study, we aimed to investigate the mechanisms underlying the effects of 6-Gingerol on hair growth. Mice were randomly divided into five groups; after hair depilation (day 0), mice were treated with saline, or different concentrations of 6-Gingerol for 11 days. The histomorphological characteristics of the growing hair follicles were examined after hematoxylin and eosin staining. The results indicated that 6-Gingerol significantly suppressed hair growth compared with that in the control group. And choose the concentration of 6-Gingerol at 1 mg/mL to treated with mice. Moreover, 6-Gingerol (1 mg/mL) significantly reduced hair re-growth ratio, hair follicle number, and hair follicle length, which were associated with increased expression of MMP2 and MMP9. Furthermore, the growth factors, such as EGF, KGF, VEGF, IGF-1 and TGF-beta participate in the hair follicle cycle regulation and regulate hair growth. We then measured the concentrations of them using ELISA assays, and the results showed that 6-Gingerol decreased EGF, KGF, VEGF, and IGF-1 concentrations, and increased TGF-beta concentration. Thus, this study showed that 6-Gingerol might act as a hair growth suppressive drug via induction of MMP2 and MMP9 expression, which could interfere with the hair cycle.
引用
收藏
页码:2707 / 2717
页数:11
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