Association between shorter leukocyte telomeres and multiple sclerosis

被引：32

作者：

Habib, Raneem ^{[1
]}

Ocklenburg, Sebastian ^{[2
]}

Hoffjan, Sabine ^{[1
]}

Haghikia, Aiden ^{[3
]}

Epplen, Joerg Thomas ^{[1
,4
]}

Arning, Larissa ^{[1
]}

机构：

[1] Ruhr Univ, Dept Human Genet, Bochum, Germany

[2] Ruhr Univ, Inst Cognit Neurosci, Dept Psychol, Biopsychol, Bochum, Germany

[3] Ruhr Univ Bochum, St Josef Hosp, Dept Neurol, Bochum, Germany

[4] Univ Witten Herdecke, Fac Hlth, Witten, Germany

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2020年 / 341卷

关键词：

Autoimmune diseases; Multiple sclerosis; Genetics; Telomere lengths; Relapsing remitting; Primary progressive; Secondary progressive; EARLY-LIFE; STRESS EXPOSURE; LENGTH; HERITABILITY; GENETICS; CELLS; AGE;

D O I：

10.1016/j.jneuroim.2020.577187

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Relative telomere length (TL) is regarded as a biomarker of biological age. Accelerated immune aging, as represented by TL reduction, has been demonstrated in autoimmune diseases, including multiple sclerosis (MS). However, it is still unresolved whether telomere shortening is the cause or the consequence of the pathogenic events underlying autoimmunity. Assessing TL in whole blood DNA samples in 138 MS patients and 120 healthy controls showed reduced TL in patients as compared with controls There seems to be a prelude of accelerated telomere shortening, which may increase the risk for development of MS.

引用

页数：5

共 40 条

[1] Lifestyle and Environmental Factors in Multiple Sclerosis
Alfredsson, Lars
Olsson, Tomas
[J]. COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 2019, 9 (04):
[2] The Genetics of Multiple Sclerosis: From 0 to 200 in 50 Years
Baranzini, Sergio E.
Oksenberg, Jorge R.
[J]. TRENDS IN GENETICS, 2017, 33 (12) : 960 - 970
[3] Tracking and fixed ranking of leukocyte telomere length across the adult life course
Benetos, Athanase
Kark, Jeremy D.
Susser, Ezra
Kimura, Masayuki
Sinnreich, Ronit
Chen, Wei
Steenstrup, Troels
Christensen, Kaare
Herbig, Utz
Hjelmborg, Jacob von Bornemann
Srinivasan, Sathanur R.
Berenson, Gerald S.
Labat, Carlos
Aviv, Abraham
[J]. AGING CELL, 2013, 12 (04) : 615 - 621
[4] Meta-analysis of telomere length in 19 713 subjects reveals high heritability, stronger maternal inheritance and a paternal age effect
Broer, Linda
Codd, Veryan
Nyholt, Dale R.
Deelen, Joris
Mangino, Massimo
Willemsen, Gonneke
Albrecht, Eva
Amin, Najaf
Beekman, Marian
de Geus, Eco J. C.
Henders, Anjali
Nelson, Christopher P.
Steves, Claire J.
Wright, Margie J.
de Craen, Anton J. M.
Isaacs, Aaron
Matthews, Mary
Moayyeri, Alireza
Montgomery, Grant W.
Oostra, Ben A.
Vink, Jacqueline M.
Spector, Tim D.
Slagboom, P. Eline
Martin, Nicholas G.
Samani, Nilesh J.
van Duijn, Cornelia M.
Boomsma, Dorret I.
[J]. EUROPEAN JOURNAL OF HUMAN GENETICS, 2013, 21 (10) : 1163 - 1168
[5] Telomere length measurement by a novel monochrome multiplex quantitative PCR method
Cawthon, Richard M.
[J]. NUCLEIC ACIDS RESEARCH, 2009, 37 (03)
[6] Defective proliferative capacity and accelerated telomeric loss of hematopoietic progenitor cells in rheumatoid arthritis
Colmegna, Ins
Diaz-Borjon, Alejandro
Fujii, Hiroshi
Schaefer, Linda
Goronzy, Joerg J.
Weyand, Cornelia M.
[J]. ARTHRITIS AND RHEUMATISM, 2008, 58 (04): : 990 - 1000
[7] Multiple sclerosis
Compston, Alastair
Coles, Alasdair
[J]. LANCET, 2008, 372 (9648) : 1502 - 1517
[8] Immunopathology of multiple sclerosis
Dendrou, Calliope A.
Fugger, Lars
Friese, Manuel A.
[J]. NATURE REVIEWS IMMUNOLOGY, 2015, 15 (09) : 545 - 558
[9] Heterogeneity in Multiple Sclerosis: Scratching the Surface of a Complex Disease
Disanto, Giulio
Berlanga, Antonio J.
Handel, Adame E.
Para, Andrea E.
Burrell, Amym M.
Fries, Anastasia
Handunnetthi, Lahiru
De Luca, Gabriele C.
Morahan, Julia M.
[J]. AUTOIMMUNE DISEASES, 2011, 2011
[10] Multiple sclerosis - a review
Dobson, R.
Giovannoni, G.
[J]. EUROPEAN JOURNAL OF NEUROLOGY, 2019, 26 (01) : 27 - 40

← 1 2 3 4 →