Fluorescence modification of Gb3 oligosaccharide and rapid synthesis of oligosaccharide moieties using fluorous protective group

被引：16

作者：

Miura, T

Tsujino, S

Satoh, A

Goto, K

Mizuno, M

Noguchi, M

Kajimoto, T

Node, M

Murakami, Y

Imai, N

Inazu, T

机构：

[1] Noguchi Inst, Itabashi Ku, Tokyo 1730003, Japan

[2] Chiba Inst Sci, Fac Pharmaceut Sci, Choshi, Chiba 2880025, Japan

[3] Kyoto Pharmaceut Univ, Yamashima Ku, Kyoto 6078412, Japan

[4] Tokai Univ, Sch Engn, Dept Appl Chem, Hiratsuka, Kanagawa 2591292, Japan

[5] Tokai Univ, Inst Glycotechnol, Hiratsuka, Kanagawa 2591292, Japan

来源：

TETRAHEDRON | 2005年 / 61卷 / 27期

基金：

日本学术振兴会;

关键词：

D O I：

10.1016/j.tet.2005.05.001

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The use of the bisfluorous chain-type propanoyl (Bfp) group as a fluorous protective group made it possible to rapidly synthesize the Gb2 and Gb3 oligosaccharide derivatives by a simple fluorous-organic extraction purification. Furthermore, the fluorescence-labeled Gb2 and Gb3 oligosaccharides were prepared as a potential Vero Toxins detecting reagent. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：6518 / 6526

页数：9

共 41 条

[1] Influence of phospholipid chain length on verotoxin/globotriaosyl ceramide binding in model membranes: Comparison of a supported bilayer film and liposomes [J].