The Potential Value of m6A RNA Methylation in the Development of Cancers Focus on Malignant Glioma

被引:16
作者
Chen, Fan [1 ]
Xie, Xuan [2 ]
Chao, Min [1 ]
Cao, Haiyan [1 ]
Wang, Liang [1 ]
机构
[1] Fourth Mil Med Univ, Tangdu Hosp, Dept Neurosurg, X'ian, Peoples R China
[2] Fourth Mil Med Univ, Xijing Hosp, Reprod Med Ctr, Dept Gynecol & Obstet, Xi'an, Peoples R China
关键词
m6A; cancer progression; GBM; immunotherapy; stem cells; STEM-LIKE CELLS; MESSENGER-RNA; HEPATOCELLULAR-CARCINOMA; M(6)A METHYLTRANSFERASE; COMPREHENSIVE ANALYSIS; METTL3; PROMOTES; EXPRESSION; PROLIFERATION; GLIOBLASTOMA; INVASION;
D O I
10.3389/fimmu.2022.917153
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
N6-methyladenosine (m6A) RNA methylation is an epigenetic modification that has emerged in the last few years and has received increasing attention as the most abundant internal RNA modification in eukaryotic cells. m6A modifications affect multiple aspects of RNA metabolism, and m6A methylation has been shown to play a critical role in the progression of multiple cancers through a variety of mechanisms. This review summarizes the mechanisms by which m6A RNA methylation induced peripheral cancer cell progression and its potential role in the infiltration of immune cell of the glioblastoma microenvironment and novel immunotherapy. Assessing the pattern of m6A modification in glioblastoma will contribute to improving our understanding of microenvironmental infiltration and novel immunotherapies, and help in developing immunotherapeutic strategies.
引用
收藏
页数:15
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