Computed tomography-identified phenotypes of small airway obstructions in chronic obstructive pulmonary disease

被引：7

作者：

Li, Tao ^{[1
,2
]}

Zhou, Hao-Peng ^{[3
]}

Zhou, Zhi-Jun ^{[4
]}

Guo, Li-Quan ^{[5
]}

Zhou, Linfu ^{[1
,6
]}

机构：

[1] Nanjing Med Univ, Affiliated Hosp 1, Dept Resp & Crit Care Med, Nanjing 210029, Jiangsu, Peoples R China

[2] Xuzhou First Peoples Hosp, Dept Resp Med, Xuzhou 221116, Jiangsu, Peoples R China

[3] Jiangsu Univ, Sch Med, Dept Med, Zhenjiang 212013, Jiangsu, Peoples R China

[4] Southeast Univ, Sch Informat & Engn, Inst Radio Frequency & Optic Elect Circuits, Nanjing 210096, Jiangsu, Peoples R China

[5] Chinese Acad Sci, Suzhou Inst Biomed Engn & Technol, Suzhou 215163, Jiangsu, Peoples R China

[6] Nanjing Med Univ, Inst Integrat Med, Nanjing 210029, Jiangsu, Peoples R China

来源：

CHINESE MEDICAL JOURNAL | 2021年 / 134卷 / 17期

基金：

中国国家自然科学基金;

关键词：

Chronic obstructive pulmonary disease; Small airway obstruction; Computed tomography; Phenotype; Pulmonary function test; LUNG-FUNCTION; CHEST CT; COPD PHENOTYPES; EMPHYSEMA; SMOKERS; EXACERBATION; MANAGEMENT; DIAGNOSIS; PATHOPHYSIOLOGY; PROGRESSION;

D O I：

10.1097/CM9.0000000000001724

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease characteristic of small airway inflammation, obstruction, and emphysema. It is well known that spirometry alone cannot differentiate each separate component. Computed tomography (CT) is widely used to determine the extent of emphysema and small airway involvement in COPD. Compared with the pulmonary function test, small airway CT phenotypes can accurately reflect disease severity in patients with COPD, which is conducive to improving the prognosis of this disease. CT measurement of central airway morphology has been applied in clinical, epidemiologic, and genetic investigations as an inference of the presence and severity of small airway disease. This review will focus on presenting the current knowledge and methodologies in chest CT that aid in identifying discrete COPD phenotypes.

引用

页码：2025 / 2036

页数：12

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