Anti-skin-aging effects of human ceramides via collagen and fibrillin expression in dermal fibroblasts

被引：6

作者：

Sugahara, Yurika ^{[1
]}

Komorisono, Masahiko ^{[1
]}

Kuwajima, Mami ^{[1
]}

Yoshikawa, Shuichi ^{[1
]}

Yoshida, Shiori ^{[2
]}

Maeda, Kazuhisa ^{[2
]}

机构：

[1] Kobayashi Pharmaceut Co Ltd, 1-30-3 Toyokawa, Ibaraki, Osaka 5670057, Japan

[2] Tokyo Univ Technol, Grad Sch Bion Comp & Media Sci, 1404-1 Katakuramachi, Hachioji, Tokyo 1920982, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2022年 / 86卷 / 09期

关键词：

ceramide; anti-aging; skin permeability; collagen; fibrillin; GROWTH-FACTOR; MATRIX; BETA;

D O I：

10.1093/bbb/zbac107

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Intercellular lipids comprise mainly ceramides, known to enhance the barrier function of the stratum corneum. However, the activities of ceramides inside the skin have not yet been fully elucidated. Here we examined how the human ceramide mixture (HC123) functions in the dermis. We treated human skin fibroblasts with HC123-expressed fibroblast growth factor (FGF), transforming growth factor-beta (TGF-beta), collagen I, and fibrillin. We found that HC123 promoted the formation of collagen fibers and microfibrils (fibrillin) which affect the elasticity of the skin. We also confirmed that the gene expression of collagen and fibrillin is promoted via TGF-beta and FGF2, respectively. We then investigated the permeability of HC123 for external use, in pursuit of evidence that HC123 may exert an anti-aging effect by penetrating into the dermis, activating fibroblasts, and promoting the production of collagen fibers and elastin-related microfibrils.

引用

页码：1240 / 1246

页数：7

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