ANTIOXIDANTS AND DIABETES MELLITUS: REVIEW OF THE EVIDENCE

被引:17
作者
Cuerda, C. [1 ]
Luengo, L. M. [2 ]
Valero, M. A. [3 ]
Vidal, A. [4 ]
Burgos, R. [5 ]
Calvo, F. L. [6 ]
Martinez, C. [7 ]
机构
[1] Univ Gregorio Maranon, Gen Hosp, Unidad Nutr, Madrid 28007, Spain
[2] Hosp Infanta Cristina, Unidad Nutr, Badajoz, Spain
[3] Hosp 12 Octubre, Unidad Nutr, E-28041 Madrid, Spain
[4] Univ Leon, Secc Endocrinol & Nutr, E-24071 Leon, Spain
[5] Hosp Valle De Hebron, Unidad Soporte Nutr, Barcelona, Spain
[6] Hosp Clin Lozano Blesa, Serv Endocrinol & Nutr, Zaragoza, Spain
[7] Univ Oviedo, Hosp Cent Asturias, Unidad Nutr, E-33080 Oviedo, Spain
关键词
Oxidative stress; Diabetes mellitus; Antioxidant; Vitamin E; Vitamin C; ENDOTHELIUM-DEPENDENT VASODILATION; ALPHA-TOCOPHEROL SUPPLEMENTATION; VITAMIN-E SUPPLEMENTATION; CORONARY-HEART-DISEASE; OXIDATIVE STRESS; BETA-CAROTENE; CARDIOVASCULAR-DISEASE; CHROMIUM SUPPLEMENTATION; INSULIN-RESISTANCE; CONTROLLED-TRIAL;
D O I
10.3305/nh.2011.26.1.5115
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Introduction: An increase in the oxidative stress and a decrease in the antioxidant levels have been described in diabetic patients, that have been related with the etiopathogenesis of diabetes and its chronic complications. Methods: We performed a non-systematic review to evaluate the relationship between oxidative stress and diabetes, and the possible effects of antioxidants in the prevention and treatment of diabetes and its complications. Results: The intervention studies including different antioxidants have not demonstrated any beneficial effect on cardiovascular and global morbimortality in different populations, including diabetic patients. Neither of these studies has demonstrated a beneficial effect of antioxidant supplementation on the prevention of diabetes. According to these studies, these substances can decrease lipid peroxidation, LDL-cholesterol particles oxidation and improve endothelial function and endothelial-dependent vasodilatation, without significant improvement in the metabolic control of these patients. Conclusions: The current evidence does not support the use of high doses of antioxidants on the prevention and treatment of diabetes and its complications. (Nutr Hosp. 2011;26:68-78) DOI:10.3305/nh.2011.26.1.5115
引用
收藏
页码:68 / 78
页数:11
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