ANTIOXIDANTS AND DIABETES MELLITUS: REVIEW OF THE EVIDENCE

被引：17

作者：

Cuerda, C. ^{[1
]}

Luengo, L. M. ^{[2
]}

Valero, M. A. ^{[3
]}

Vidal, A. ^{[4
]}

Burgos, R. ^{[5
]}

Calvo, F. L. ^{[6
]}

Martinez, C. ^{[7
]}

机构：

[1] Univ Gregorio Maranon, Gen Hosp, Unidad Nutr, Madrid 28007, Spain

[2] Hosp Infanta Cristina, Unidad Nutr, Badajoz, Spain

[3] Hosp 12 Octubre, Unidad Nutr, E-28041 Madrid, Spain

[4] Univ Leon, Secc Endocrinol & Nutr, E-24071 Leon, Spain

[5] Hosp Valle De Hebron, Unidad Soporte Nutr, Barcelona, Spain

[6] Hosp Clin Lozano Blesa, Serv Endocrinol & Nutr, Zaragoza, Spain

[7] Univ Oviedo, Hosp Cent Asturias, Unidad Nutr, E-33080 Oviedo, Spain

来源：

NUTRICION HOSPITALARIA | 2011年 / 26卷 / 01期

关键词：

Oxidative stress; Diabetes mellitus; Antioxidant; Vitamin E; Vitamin C; ENDOTHELIUM-DEPENDENT VASODILATION; ALPHA-TOCOPHEROL SUPPLEMENTATION; VITAMIN-E SUPPLEMENTATION; CORONARY-HEART-DISEASE; OXIDATIVE STRESS; BETA-CAROTENE; CARDIOVASCULAR-DISEASE; CHROMIUM SUPPLEMENTATION; INSULIN-RESISTANCE; CONTROLLED-TRIAL;

D O I：

10.3305/nh.2011.26.1.5115

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Introduction: An increase in the oxidative stress and a decrease in the antioxidant levels have been described in diabetic patients, that have been related with the etiopathogenesis of diabetes and its chronic complications. Methods: We performed a non-systematic review to evaluate the relationship between oxidative stress and diabetes, and the possible effects of antioxidants in the prevention and treatment of diabetes and its complications. Results: The intervention studies including different antioxidants have not demonstrated any beneficial effect on cardiovascular and global morbimortality in different populations, including diabetic patients. Neither of these studies has demonstrated a beneficial effect of antioxidant supplementation on the prevention of diabetes. According to these studies, these substances can decrease lipid peroxidation, LDL-cholesterol particles oxidation and improve endothelial function and endothelial-dependent vasodilatation, without significant improvement in the metabolic control of these patients. Conclusions: The current evidence does not support the use of high doses of antioxidants on the prevention and treatment of diabetes and its complications. (Nutr Hosp. 2011;26:68-78) DOI:10.3305/nh.2011.26.1.5115

引用

页码：68 / 78

页数：11

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