Spare and repair the gut microbiota from antibiotic-induced dysbiosis: state-of-the-art

被引：23

作者：

Andremont, Antoine ^{[1
,2
]}

Cervesi, Julie ^{[1
]}

Bandinelli, Pierre-Alain ^{[1
]}

Vitry, Fabien ^{[1
]}

de Gunzburg, Jean ^{[1
]}

机构：

[1] Da Volterra, Paris, France

[2] Univ Paris, IAME, INSERM, Paris, France

来源：

DRUG DISCOVERY TODAY | 2021年 / 26卷 / 09期

关键词：

INTESTINAL MICROBIOTA; CLOSTRIDIUM-DIFFICILE; FECAL MICROBIOTA; RESISTANCE; COLONIZATION; CONVERGENCE; PENICILLIN; ADSORBENT; BACTERIA; P1A;

D O I：

10.1016/j.drudis.2021.02.022

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Homeostasis of the intestinal microbiota is currently recognized as a major contributor to human health. Furthermore, intestinal dysbiosis is associated with a multitude of consequences, including intestinal colonization by antibiotic-resistant or pathogenic bacteria, such as Clostridioides difficile, and reduced efficacy of promising anticancer immunotherapies. By far, the most immediate and drastic exposure leading to dysbiosis is antibiotic treatment. Many attempts have been made to prevent or repair antibiotic-associated dysbiosis. Here, we review these innovations and the difficulties associated with their development.

引用

收藏

页码：2159 / 2163

页数：5

相关论文

共 59 条

[1] Too Early to Recommend Early Fecal Microbiota Transplantation in Patients With Severe Clostridium difficile Infection, or Not Too Early? [J].

Andremont, Antoine .

CLINICAL INFECTIOUS DISEASES, 2018, 66 (05) :651-652

[2] The microbiome as a human organ [J].

Baquero, F. ;

Nombela, C. .

CLINICAL MICROBIOLOGY AND INFECTION, 2012, 18 :2-4

[3] Antibiotic-Induced Changes in the Intestinal Microbiota and Disease [J].

Becattini, Simone ;

Taur, Ying ;

Pamer, Eric G. .

TRENDS IN MOLECULAR MEDICINE, 2016, 22 (06) :458-478

[4] Candida albicans induces mucosal bacterial dysbiosis that promotes invasive infection [J].

Bertolini, Martinna ;

Ranjan, Amit ;

Thompson, Angela ;

Diaz, Patricia, I ;

Sobue, Takanori ;

Maas, Kendra ;

Dongari-Bagtzoglou, Anna .

PLOS PATHOGENS, 2019, 15 (04)

[5] SELECTIVE MEDIA FOR DETECTING AND ENUMERATING FOODBORNE YEASTS [J].

BEUCHAT, LR .

INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY, 1993, 19 (01) :1-14

[6]

Burdet C, 2018, ANTIMICROB AGENTS CH, V62, DOI [10.1128/AAC.00925-18, 10.1128/aac.00925-18]

[7]

Burdet C, 2017, ANTIMICROB AGENTS CH, V61, DOI [10.1128/AAC.00543-17, 10.1128/aac.00543-17]

[8] The gut is the epicentre of antibiotic resistance [J].

Carlet, Jean .

ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL, 2012, 1

[9] PRESENCE OF CLOSTRIDIUM-DIFFICILE AND ANTIBIOTIC AND BETA-LACTAMASE ACTIVITIES IN FECES OF VOLUNTEERS TREATED WITH ORAL CEFIXIME, ORAL CEFPODOXIME PROXETIL, OR PLACEBO [J].

CHACHATY, E ;

DEPITRE, C ;

MARIO, N ;

BOURNEIX, C ;

SAULNIER, P ;

CORTHIER, G ;

ANDREMONT, A .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1992, 36 (09) :2009-2013

[10] Enterotypes in the landscape of gut microbial community composition [J].

Costea, Paul I. ;

Hildebrand, Falk ;

Manimozhiyan, Arumugam ;

Backhed, Fredrik ;

Blaser, Martin J. ;

Bushman, Frederic D. ;

de Vos, Willem M. ;

Ehrlich, S. Dusko ;

Fraser, Claire M. ;

Hattori, Masahira ;

Huttenhower, Curtis ;

Jeffery, Ian B. ;

Knights, Dan ;

Lewis, James D. ;

Ley, Ruth E. ;

Ochman, Howard ;

O'Toole, Paul W. ;

Quince, Christopher ;

Relman, David A. ;

Shanahan, Fergus ;

Sunagawa, Shinichi ;

Wang, Jun ;

Weinstock, George M. ;

Wu, Gary D. ;

Zeller, Georg ;

Zhao, Liping ;

Raes, Jeroen ;

Knight, Rob ;

Bork, Peer .

NATURE MICROBIOLOGY, 2018, 3 (01) :8-16

← 1 2 3 4 5 6 →