808 nm laser triggered self-monitored photo-thermal therapeutic nano-system Y2O3: Nd3+/Yb3+/Er3+@SiO2@Cu2S

被引：30
作者：
Zhang, Zhiyu [1 ]
Suo, Hao [1 ]
Zhao, Xiaoqi [1 ]
Guo, Chongfeng [1 ]
机构：
[1] Northwest Univ, Inst Photon & Photon Technol, Natl Photoelect Technol & Funct Mat & Applicat Sc, Natl Key Lab Photoelect Technol & Funct Mat Cultu, Xian 710069, Peoples R China
来源：
PHOTONICS RESEARCH | 2020年 / 8卷 / 01期
基金：
中国国家自然科学基金;
关键词：
UP-CONVERSION NANOPARTICLES; CANCER; SENSITIVITY;
D O I：
10.1364/PRJ.8.000032
中图分类号：
O43 [光学];
学科分类号：
070207 ; 0803 ;
摘要：
A multifunctional photo-thermal therapeutic nano-platform Y2O3: Nd3+/Yb3+/Er3+@SiO2@Cu2S was designed through a core-shell structure, expressing the function of bio-tissue imaging, real-time temperature detection, and photo-thermal therapy under 808 nm light excitation. In this system, the core Y2O3: Nd3+/Yb3+ /Er3+ (YR) takes the responsibility of emitting optical information and monitoring temperature, while the shell Cu2S nano-particles carry most of the photo-thermal conversion function. The temperature sensing characteristic was achieved by the fluorescence intensity ratio using the thermally coupled energy levels (TCLs) S-4(3)/2/ H-2(11)/2 of Er3+, and its higher accuracy fur real-time temperature measurement in the bio-tissue than that of an infrared thermal camera was also proved by sub-tissue experiments. Furthermore, the photo-thermal effect of the present nano-system Y2O3: Nd3+/Yb3+/Er3+@SiO2@Cu2S was confirmed by Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) ablation. Results indicate that YR-Si-Cu2S has application prospect in temperature-controlled photo-thermal treatment and imaging in bio-tissues. (C) 2019 Chinese Laser Press
引用
收藏
页码：32 / 38
页数：7
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