Synthesis of protected 4-deoxyaklanonic acid via naphthalene-substituted oligoketides

被引：0
|
作者：
Krohn, K
Schafer, G
机构：
来源：
LIEBIGS ANNALEN | 1996年 / 02期
关键词：
aklanonic acid; Baker-Venkataraman rearrangement; biomimetic synthesis; polyketides;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Ketide side chains (C-4) Were attached to the naphthoquinone 3 by reaction with the dienes 4 or 14 followed by Baker-Venkataraman rearrangement of esters 8 and 17 to attach the second protected beta-diketo side chain. Linear anellations of the corresponding naphthoquinone precursors 9 and 17 to the 4-deoxyaklanonic acids 10 and 18a, respectively, were effected in a base-catalyzed cascade of reactions (e.g, only three operations from 3 to 18a).
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页码：265 / 270
页数：6
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