Regulation of axonal development by plasma membrane gangliosides

被引：18

作者：

Abad-Rodriguez, Jose

Robotti, Andrea

机构：

[1] Catholic Univ Louvain, Flanders Interuniv Inst Biotechnol VIB11, Dept Mol & Dev Genet, B-3000 Louvain, Belgium

[2] Univ Turin, Fondaz Cavalieri Ottolenghi, Turin, Italy

来源：

JOURNAL OF NEUROCHEMISTRY | 2007年 / 103卷

关键词：

actin; axon; ganglioside; neurotrophins; plasma; membrane ganglioside sialidase/Neu3;

D O I：

10.1111/j.1471-4159.2007.04713.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Gangliosides present in the plasma membrane participate in fundamental processes during neuronal development. From the determination and the outgrowth of the axon, to the growth inhibitory activity produced after CNS injury, local interconversion of these glycosphingolipids regulate actin dynamics in a spatially restricted manner by modulating membrane receptors and their downstream signaling pathways. Here, we will review the possible mechanisms underlying these modulations and the potential importance of gangliosides and ganglioside-transforming enzymes as therapeutic targets.

引用

页码：47 / 55

页数：9

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