Bromodomain Inhibition in Diffuse Large B-cell Lymphoma-Giving MYC a Brake

被引：17
|
作者：
Mottok, Anja [1 ,2 ]
Gascoyne, Randy D. [1 ,2 ]
机构：
[1] British Columbia Canc Agcy, Ctr Lymphoid Canc, Vancouver, BC V5Z 1L3, Canada
[2] Univ British Columbia, Dept Pathol & Lab Med, Vancouver, BC V5Z 1M9, Canada
来源：
CLINICAL CANCER RESEARCH | 2015年 / 21卷 / 01期
关键词：
RITUXIMAB PLUS CYCLOPHOSPHAMIDE; BET BROMODOMAINS; VINCRISTINE; DOXORUBICIN; PREDNISONE; EXPRESSION; CANCER;
D O I：
10.1158/1078-0432.CCR-14-1651
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Bromodomains are conserved protein regions that function as epigenetic readers by recognizing specific histone modifications. The common association of bromodomains with enhancer and super-enhancer regions in diffuse large B-cell lymphoma contributes to its pathogenesis. Bromodomain inhibition reduces tumor growth largely through the disruption of transcriptional networks driven by oncogenic MYC. (C) 2014 AACR.
引用
收藏
页码：4 / 6
页数：3
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