LRP5 gene polymorphism and cortical bone

被引:2
|
作者
Lauretani, Fulvio [1 ]
Cepollaro, Chiara [2 ]
Bandinelli, Stefania [3 ]
Cherubini, Antonio [4 ]
Gozzini, Alessia [2 ]
Masi, Laura [2 ]
Falchetti, Alberto [2 ]
Del Monte, Francesca [2 ]
Carbonell-Sala, Silvia [2 ]
Marini, Francesca [2 ]
Tanini, Annalisa [2 ]
Corsi, Anna Maria
Ceda, Gian Paolo [5 ]
Brandi, Maria Luisa [2 ]
Ferrucci, Luigi [6 ]
机构
[1] Univ Hosp Parma, Dept Geriatr Rehabil, Geriatr Unit, I-40130 Parma, Italy
[2] Univ Florence, Dept Internal Med & Spin Off DeGene, Florence, Italy
[3] Azienda Sanitaria Firenze, Geriatr Unit, Florence, Italy
[4] Univ Perugia, Sch Med, Inst Gerontol & Geriatr, I-06100 Perugia, Italy
[5] Univ Hosp Parma, Geriatr Clin, Parma, Italy
[6] NIA, Longitudinal Studies Sect, Clin Res Branch, NIH, Baltimore, MD 21224 USA
关键词
Cortical bone area; LRP5 gene polymorphism; osteoporosis; peripheral bone quantitative computed tomography (pQCT); volumetric BMD; MINERAL DENSITY; PROTEIN-5; GENE; ASSOCIATION; OSTEOPOROSIS; MUTATIONS; FRACTURES; MASS; BMD; POPULATION; VALIDITY;
D O I
10.1007/BF03324935
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Background and aims: There is evidence that distinct genetic polymorphisms of LRP5 are associated with low Bone Mineral Density (BMD) and the risk of fracture. However, relationships between LRP5 polymorphisms and micro- and macro-architectural bone characteristics assessed by pQCT have not been studied. The aim of the present study was to investigate the association of Ala1330Val and Va1667Met polymorphisms in LRP5 gene with volumetric BMD (vBMD) and macro-architectural bone parameters in a population-based sample of men and women. Methods: We studied 959 participants of the InCHIANTI study (451 men and 508 women, age range: 21-94 yrs). Trabecular vBMD (vBMDt, mg/cm(3)), cortical vBMD (vBMDc, mg/cm(3)), cortical bone area (CBA, mm(2)) and cortical thickness (Ct.Th, mm) at the level of the tibia were assessed by peripheral quantitative computed tomography (pQCT). Ala1330Val and Va1667Met genotypes were determined on genomic DNA by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: In age-adjusted analyses both LRP 1330-valine and LRP 667-metionin variants were associated with lower vBMDt in men (p<0.05), and lower vBMDt (p<0.05), Ct.Th (p<0.05) and CBA (p<0.05) in women. After adjusting for multiple confounders, only the association of LRP5 1330-valine and 667-metionin with CBA remained statistically significant (p=0.04 and p=0.01, respectively) in women. Conclusion: These findings suggest that both Ala1330Val and Va1667Met LRP5 polymorphisms may affect the determination of geometric bone parameters in women. (Aging Clin Exp Res 2010; 22: 281-288) (C) 2010, Editrice Kurtis
引用
收藏
页码:281 / 288
页数:8
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