HYPONATREMIA IN VISCERAL LEISHMANIASIS

被引：7

作者：

Lima Verde, Frederico A. ^{[1
,3
]}

Lima Verde, Francisco A. A. ^{[1
]}

Veronese, Francisco Jose V. ^{[3
]}

Neto, Augusto S. ^{[1
]}

Fuc, Galdino ^{[1
]}

Lima Verde, Emir M. ^{[1
,2
]}

机构：

[1] INECE, Fortaleza, Ceara, Brazil

[2] Univ Fed Ceara, Sch Med, Dept Internal Med, Fortaleza, Ceara, Brazil

[3] Univ Fed Rio Grande do Sul, Div Nephrol, BR-90046900 Porto Alegre, RS, Brazil

来源：

REVISTA DO INSTITUTO DE MEDICINA TROPICAL DE SAO PAULO | 2010年 / 52卷 / 05期

关键词：

Hyponatremia; Hypo-osmolality; Hypouricemia; Syndrome of inappropriate antidiuretic hormone secretion; Visceral leishmaniasis; ANTIDIURETIC-HORMONE SECRETION; COLLOID OSMOTIC-PRESSURE; PITUITARY-ADRENAL AXIS; KALA-AZAR; INAPPROPRIATE SECRETION; RENAL-FUNCTION; INTERLEUKIN-6; METABOLISM; CHILDREN; DONOVANI;

D O I：

10.1590/S0036-46652010000500006

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

There are few reports linking hyponatremia and visceral leishmaniasis (kala-azar). This is a study of 55 consecutive kala-azar patients and 20 normal individuals as a control group. Hyponatremia and serum hypo-osmolality were detected in 100% of kala-azar patients. High first morning urine osmolality (750.0 +/- 52.0 vs. 894.5 +/- 30.0mOsm/kg H2O, p < 0.05), and high 24-hour urine osmolality (426.0 +/- 167.0 vs. 514.6 +/- 132.0 mOsm/kg H2O, p < 0.05) demonstrated persistent antidiuretic hormone secretion. Urinary sodium was high (82.3 +/- 44.2 vs. 110.3 +/- 34.7 mEq/L, p < 0.05). Low seric uric acid occurred in 61.8% of patients and increased fractional urinary uric acid excretion was detected in 74.5% of them. Increased glomerular filtration rate was present in 25.4% of patients. There was no evidence of extracellular volume depletion. Normal plasma ADH levels were observed in kala-azar patients. No endocrine or renal dysfunction was detected. It is possible that most hyponatremic kala-azar patients present the syndrome of inappropriate antidiuretic hormone secretion.

引用

页码：253 / 258

页数：6

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