Muscle stem cell and physical activity: what point is the debate at?

被引:10
作者
Ceccarelli, Gabriele [3 ,4 ]
Benedetti, Laura [3 ,4 ]
Arcari, Maria Luisa [5 ]
Carubbi, Cecilia [5 ]
Galli, Daniela [1 ,2 ,5 ]
机构
[1] Univ Parma, Dept Med & Surg, SBiBiT Unit, Osped Maggiore, Via Gramsci 14, I-43126 Parma, Italy
[2] Univ Parma, Sport & Exercise Med Ctr SEM, Via Gramsci 14, I-43126 Parma, Italy
[3] Univ Pavia, Dept Publ Hlth Expt Med & Forens, Pavia, Italy
[4] Univ Pavia, Ctr Hlth Technol, Pavia, Italy
[5] Univ Parma, SBiBiT Unit, Dept Med & Surg, Parma, Italy
关键词
Stem cell; Physical exercise; Cardiac muscle; Skeletal muscle; SKELETAL-MUSCLE; SATELLITE CELL; GENE-EXPRESSION; CARDIAC-HYPERTROPHY; ATHLETES HEART; MESSENGER-RNA; EXERCISE; ENDURANCE; YOUNG; PROLIFERATION;
D O I
10.1515/med-2017-0022
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
In the last 15 years, it emerged that the practice of regular physical activity reduces the risks of many diseases (cardiovascular diseases, diabetes, etc.) and it is fundamental in weight control and energy consuming to contrast obesity. Different groups proposed many molecular mechanisms as responsible for the positive effects of physical activity in healthy life. However, many points remain to be clarified. In this mini-review we reported the latest observations on the effects of physical exercise on healthy skeletal and cardiac muscle focusing on muscle stem cells. The last ones represent the fundamental elements for muscle regeneration post injury, but also for healthy muscle homeostasis. Interestingly, in both muscle tissues the morphological consequence of physical activity is a physiological hypertrophy that depends on different phenomena both in differentiated cells and stem cells. The signaling pathways for physical exercise effects present common elements in skeletal and cardiac muscle, like activation of specific transcription factors, proliferative pathways, and cytokines. More recently, post translational (miRNAs) or epigenetic (DNA methylation) modifications have been demonstrated. However, several points remain unresolved thus requiring new research on the effect of exercise on muscle stem cells.
引用
收藏
页码:144 / 156
页数:13
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