Intravenous thrombolysis for acute ischemic stroke

被引：14
作者：
Turc, G. [1 ,2 ,3 ]
Isabel, C. [1 ,2 ]
Calvet, D. [1 ,2 ,3 ]
机构：
[1] St Anne Hosp, Stroke Unit, F-75014 Paris, France
[2] Univ Paris 05, Sorbonne Paris Cite, Paris, France
[3] INSERM, UMR S894, F-75654 Paris 13, France
来源：
DIAGNOSTIC AND INTERVENTIONAL IMAGING | 2014年 / 95卷 / 12期
关键词：
Stroke; Ischemia; Thrombolysis; Interventional radiology; Thrombectomy; TISSUE-PLASMINOGEN ACTIVATOR; SYMPTOM ONSET; WAKE-UP; TIME; RECANALIZATION; ALTEPLASE; TRIAL; HEMORRHAGE; MINUTES; THERAPY;
D O I：
10.1016/j.diii.2014.10.002
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Intravenous thrombolysis ( IVT) with alteplase remains the standard treatment for acute ischemic stroke. Although IVT can be started up to 4.5 hours after symptoms' onset, it is all the more effective and safe when started early. It allows a 10% absolute reduction in the risk of handicap or death at 3 months, despite a 2- 7% risk of symptomatic intracranial hemorrhage. Current research efforts involve firstly trying to treat a larger proportion of patients by over-coming some of the contraindications to IVT and secondly assessing combined or alternative treatments to achieve a higher early recanalization rate.(C) 2014 editions francaises de radiologie.Published by Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：1129 / 1133
页数：5
相关论文
共 38 条
  • [1] Implementation and outcome of thrombolysis with alteplase 3-4.5 h after an acute stroke: an updated analysis from SITS-ISTR
    Ahmed, Niaz
    Wahlgren, Nils
    Grond, Martin
    Hennerici, Michael
    Lees, Kennedy R.
    Mikulik, Robert
    Parsons, Mark
    Roine, Risto O.
    Toni, Danilo
    Ringleb, Peter
    [J]. LANCET NEUROLOGY, 2010, 9 (09) : 866 - 874
  • [2] Ultrasound-enhanced systemic thrombolysis for acute ischemic stroke
    Alexandrov, AV
    Molina, CA
    Grotta, JC
    Garami, Z
    Ford, SR
    Alvarez-Sabin, J
    Montaner, J
    Saqqur, M
    Demchuk, AM
    Moye, LA
    Hill, MD
    Wojner, AW
    Al-Senani, F
    Burgin, S
    Calleja, S
    Campbell, M
    Chen, CI
    Chernyshev, O
    Choi, J
    El-Mitwalli, A
    Felberg, R
    Ford, S
    Garami, Z
    Irr, W
    Grotta, J
    Hall, C
    Iguchi, Y
    Ireland, J
    Labiche, L
    Malkoff, M
    Morgenstern, L
    Noser, E
    Okon, N
    Piriyawat, P
    Robinson, D
    Shaltoni, H
    Shaw, S
    Uchino, K
    Yatsu, F
    Alvarez-Sabín, J
    Arenillas, JF
    Huertas, R
    Molina, C
    Montaner, J
    Ribó, M
    Rubiera, M
    Santamarina, E
    Saqqur, M
    Alchtar, N
    O'Rourke, F
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2004, 351 (21) : 2170 - 2178
  • [3] [Anonymous], ACCIDENT VASCULAIRE
  • [4] [Anonymous], 2014, LANCET
  • [5] [Anonymous], KAROLINSKA STROKE UP
  • [6] Thrombolytic Therapy for Patients Who Wake-Up With Stroke
    Barreto, Andrew D.
    Martin-Schild, Sheryl
    Hallevi, Hen
    Morales, Miriam M.
    Abraham, Anitha T.
    Gonzales, Nicole R.
    Illoh, Kachi
    Grotta, James C.
    Savitz, Sean I.
    [J]. STROKE, 2009, 40 (03) : 827 - 832
  • [7] Endovascular Therapy after Intravenous t-PA versus t-PA Alone for Stroke
    Broderick, Joseph P.
    Palesch, Yuko Y.
    Demchuk, Andrew M.
    Yeatts, Sharon D.
    Khatri, Pooja
    Hill, Michael D.
    Jauch, Edward C.
    Jovin, Tudor G.
    Yan, Bernard
    Silver, Frank L.
    von Kummer, Ruediger
    Molina, Carlos A.
    Demaerschalk, Bart M.
    Budzik, Ronald
    Clark, Wayne M.
    Zaidat, Osama O.
    Malisch, Tim W.
    Goyal, Mayank
    Schonewille, Wouter J.
    Mazighi, Mikael
    Engelter, Stefan T.
    Anderson, Craig
    Spilker, Judith
    Carrozzella, Janice
    Ryckborst, Karla J.
    Janis, L. Scott
    Martin, Renee H.
    Foster, Lydia D.
    Tomsick, Thomas A.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2013, 368 (10) : 893 - 903
  • [8] Time to recanalization and risk of symptomatic intracerebral haemorrhage in patients treated with intravenous thrombolysis
    Dorado, L.
    Millan, M.
    Perez de la Ossa, N.
    Guerrero, C.
    Gomis, M.
    Aleu, A.
    Lopez-Cancio, E.
    Cuadras, P.
    Davalos, A.
    [J]. EUROPEAN JOURNAL OF NEUROLOGY, 2012, 19 (09) : 1251 - 1255
  • [9] Effect of the Use of Ambulance-Based Thrombolysis on Time to Thrombolysis in Acute Ischemic Stroke A Randomized Clinical Trial
    Ebinger, Martin
    Winter, Benjamin
    Wendt, Matthias
    Weber, Joachim E.
    Waldschmidt, Carolin
    Rozanski, Michal
    Kunz, Alexander
    Koch, Peter
    Kellner, Philipp A.
    Gierhake, Daniel
    Villringer, Kersten
    Fiebach, Jochen B.
    Grittner, Ulrike
    Hartmann, Andreas
    Mackert, Bruno-Marcel
    Endres, Matthias
    Audebert, Heinrich J.
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2014, 311 (16): : 1622 - 1631
  • [10] Selective neuronal loss in rescued penumbra relates to initial hypoperfusion
    Guadagno, J. V.
    Jones, P. S.
    Aigbirhio, F. I.
    Wang, D.
    Fryer, T. D.
    Day, D. J.
    Antoun, N.
    Nimmo-Smith, I.
    Warburton, E. A.
    Baron, J. C.
    [J]. BRAIN, 2008, 131 : 2666 - 2678
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