The multifaceted effects of metformin on tumor microenvironment

被引：59

作者：

Kurelac, Ivana ^{[1
]}

Ganesh, Nikkitha Umesh ^{[1
]}

Iorio, Maria ^{[1
]}

Porcelli, Anna Maria ^{[2
,3
]}

Gasparre, Giuseppe ^{[1
,4
]}

机构：

[1] Univ Bologna, Dipartimento Sci Med & Chirurg, Via Massarenti 9, I-40138 Bologna, Italy

[2] Univ Bologna, Dipartimento Farm & Biotecnol, Via Selmi 3, I-40126 Bologna, Italy

[3] Univ Bologna, Ctr Interdipartimentale Ric Ind Sci Vita & Tecnol, Via Tolara 41-E, I-40064 Ozzano Dell Emilia, Italy

[4] Univ Bologna, CRBA, Via Massarenti 9, I-40138 Bologna, Italy

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2020年 / 98卷

关键词：

Cancer metabolism; Metformin; Respiratory complex I; Tumor microenvironment; Angiogenesis; Cancer-associated fibroblasts; Tumor-associated macrophages; Cancer immunosuppression; BREAST-CANCER; MACROPHAGE POLARIZATION; INFLAMMATORY RESPONSE; COMPLEX I; GROWTH; INHIBITION; ANGIOGENESIS; PROGRESSION; ACTIVATION; MECHANISMS;

D O I：

10.1016/j.semcdb.2019.05.010

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The efficacy of metformin in treating cancer has been extensively investigated since epidemiologic studies associated this anti-diabetic drug with a lower risk of cancer incidence. Since tumors are complex systems, in which cancer cells coexist and interact with several different types of non-malignant cells, it is not surprising that anti-cancer drugs affect not only cancer cells, but also the abundance and functions of cells of the tumor microenvironment. Recent years have seen a wide collection of reports showing how metformin, as well as other complex I inhibitors, may influence cancer progression by modulating the phenotype of non-transformed cells in a tumor. In this review, we particularly focus on the effect of metformin on angiogenesis, cancer-associated fibroblasts, tumor-associated macrophages and cancer immunosuppression.

引用

页码：90 / 97

页数：8

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