Biological functions, regulatory mechanisms, and disease relevance of RNA localization pathways

被引：23

作者：

Bovaird, Samantha ^{[1
,2
]}

Patel, Dhara ^{[1
,3
]}

Padilla, Juan-Carlos Alberto ^{[1
,2
]}

Lecuyer, Eric ^{[1
,2
,3
,4
]}

机构：

[1] IRCM, 110 Ave Pins Ouest, Montreal, PQ, Canada

[2] McGill Univ, Div Expt Med, Fac Med, Montreal, PQ, Canada

[3] Univ Montreal, Mol Biol Program, Fac Med, Montreal, PQ, Canada

[4] Univ Montreal, Dept Biochem & Mol Med, Montreal, PQ, Canada

来源：

FEBS LETTERS | 2018年 / 592卷 / 17期

基金：

加拿大健康研究院;

关键词：

Cis-regulatory elements; RNA disease; RNA localization; RNA-binding proteins; ACTIN MESSENGER-RNA; AMYOTROPHIC-LATERAL-SCLEROSIS; STEM-LOOP STRUCTURE; TRANSCRIPTOME-WIDE IDENTIFICATION; SPLICING FACTOR SRSF1; LONG NONCODING RNAS; BINDING PROTEINS; REPEAT EXPANSION; PHASE-SEPARATION; MYOTONIC-DYSTROPHY;

D O I：

10.1002/1873-3468.13228

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The asymmetric subcellular distribution of RNA molecules from their sites of transcription to specific compartments of the cell is an important aspect of post-transcriptional gene regulation. This involves the interplay of intrinsic cis-regulatory elements within the RNA molecules with trans-acting RNA-binding proteins and associated factors. Together, these interactions dictate the intracellular localization route of RNAs, whose downstream impacts have wide-ranging implications in cellular physiology. In this review, we examine the mechanisms underlying RNA localization and discuss their biological significance. We also review the growing body of evidence pointing to aberrant RNA localization pathways in the development and progression of diseases.

引用

页码：2948 / 2972

页数：25

共 311 条

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