Synthesis of some aryl (pyrimidin-3-yl)methyl ureas, hydrazones and semicarbazones

被引：1

作者：

Jakubkiene, Virginija ^{[1
]}

Zurba, Justinas ^{[1
]}

Burbuliene, Milda M. ^{[1
]}

机构：

[1] Vilnius State Univ, Fac Chem, Dept Organ Chem, Naugarduko 24, LT-03225 Vilnius, Lithuania

来源：

ARKIVOC | 2016年

关键词：

(Pyrimidin-3-yl)acetyl azides; aryl (pyrimidin-3-yl)ureas; hydrazones; semicarbazones; ANTIINFLAMMATORY ACTIVITY; ANTIMICROBIAL EVALUATION; SULFONAMIDE MOIETIES; DERIVATIVES; DISCOVERY; ANTIBACTERIAL; AGENTS; AZIDES; EFFICACY; THIOUREA;

D O I：

10.3998/ark.5550190.p009.620

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two methods of synthesis of aryl (pyrimidin-3-yl)methyl ureas were investigated. One of them involved reaction sequence starting with (pyrimidin-3-yl)acetohydrazides to give the corresponding azides, which reacted with aryl amines to form aryl (pyrimidin-3-yl)methyl ureas. The second one was based on a one-pot reaction of (pyrimidin-3-yl)acetic acids with diphenyl phosphoryl azide followed by reaction with aryl amines. Also, some new aryl and (pyrimidin-3-yl)moiety bearing hydrazones and semicarbazones were synthesized.

引用

页码：374 / 386

页数：13

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